5-bromo-2,3,3-trimethyl-2,3-dihydro-1H-indole | 304468-38-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-bromo-2,3,3-trimethyl-2,3-dihydro-1H-indole
• 英文别名: (l)-2,3,3-trimethyl-5-bromo-3H-indoline；2,3,3-trimethyl-5-bromo-3H-indoline；5-Bromo-2,3,3-trimethylindoline；5-bromo-2,3,3-trimethyl-1,2-dihydroindole
• CAS: 304468-38-0
• 化学式: C₁₁H₁₄BrN
• 分子量: 240.143
• InChiKey: FQEMQDFCCFMOAL-UHFFFAOYSA-N

物化性质

• 沸点：
  290.8±39.0 °C(Predicted)
• 密度：
  1.269±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-bromo-2,3,3-trimethyl-2,3-dihydro-1H-indole 在 sodium hydroxide 作用下， 以 四氢呋喃 、 水 、 乙腈 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  Narrow band green organic photodiodes for imaging

  摘要：

  Accurate color reproduction using image sensors requires four narrow-band absorbing photodetectors (blue, green, yellow and red). Current photodetectors use a broadband photodetector in combination with color filters, which generally do not have sufficient wavelength discrimination for illuminant independent color recognition. We have developed a green-sensitive organic photodetector, in which color selection is achieved using a narrow-absorbing ketocyanine chromophore, coupled with a low finesse electro-optical cavity inducing further spectral narrowing. The optimized device contained a bulk heterojunction light-absorbing layer comprised of a ketocyanine dye blended with [6,6]phenyl-C-61-butyric acid methyl ester. The photodetector had a response full width at half maximum of 80 nm centered around 525 nm, and an external quantum efficiency of 15% at -1.0 V, which is the highest so far reported for a narrow band green-absorbing organic photodetector. The performance of this detector is sufficient to meet the specifications required by machine vision systems. Crown Copyright (C) 2014 Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.orgel.2014.08.015

文献信息

• 3,3-substituted indoline derivatives
  申请人：WYETH

  公开号：US20030008909A1

  公开（公告）日：2003-01-09

  This invention provides compounds of the formula I: 1 wherein: R 1 and R 2 are independently H, OH, OAc, alkylaryl, alkylheteroaryl, 1-propynyl, 3-propynyl, and substituted alkyl, O(alkyl), aryl, or heteroaryl; or R 1 and R 2 are joined to form a ring comprising —CH 2 (CH 2 ) n CH 2 — where n=0-5; —CH 2 CH 2 C(CH 3 ) 2 CH 2 CH 2 —; —O(CH 2 ) m CH 2 — where m=1-4; O(CH 2 ) p O— where p=1-4; —CH 2 CH 2 OCH 2 CH 2 —; —CH 2 CH 2 N(H or alkyl)CH 2 CH 2 —; or R 1 and R 2 together comprise a double bond to C(CH 3 ) 2 , C(cycloalkyl), O, or C(cycloether); R 3 is H, OH, NH 2 , COR A , or optionally substituted alkenyl or alkynyl groups; R A =H or optionally substituted alkyl, alkoxy, or aminoalkyl groups; R 4 =H, halo, CN, NH 2 , or optionally substituted alkyl, alkoxy, or aminoalkyl; R 5 is optionally substituted benzene ring; five or six membered heterocyclic ring; 4 or 7-substituted indole or a substituted benzothiophene; or pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and methods of using the compounds as progesterone receptor antagonists.

  本发明提供了式I的化合物：1其中：R1和R2分别为H、OH、OAc、烷基芳基、烷基杂芳基、1-丙炔基、3-丙炔基和取代烷基、O（烷基）、芳基或杂芳基；或者R1和R2结合形成包括—CH2（ ）n —的环，其中n=0-5；— C（CH3）2 —；—O（ ）m —其中m=1-4；O（ ）pO—其中p=1-4；— O —；— N（H或烷基） —；或者R1和R2一起包括双键到C（ ）2、C（环烷基）、O或C（环醚）；R3为H、OH、NH2、CORA或者可选取代的烯基或炔基基团；RA=H或者可选取代的烷基、烷氧基或氨基烷基基团；R4=H、卤素、CN、NH2或者可选取代的烷基、烷氧基或氨基烷基；R5为可选取代的苯环、五元或六元杂环、4或7-取代吲哚或取代苯并噻吩；或其药学上可接受的盐，以及将该化合物用作孕激素受体拮抗剂的药物组合物和方法。
• Combination regimens using 3,3-substituted indoline derivatives
  申请人：American Home Products Corporation

  公开号：US20020035099A1

  公开（公告）日：2002-03-21

  This invention relates to cyclic combination therapies and regimens utilizing substituted indoline derivative compounds that are antagonists of the progesterone receptor having the general structure: 1 wherein: R 1 , and R 2 are chosen independently from each other from H, OH; OAc; alkylaryl; alkylheteroaryl; 1-propynyl; 3-propynyl; and optionally substituted alkyl, O(alkyl); aryl; or heteroaryl groups; or R 1 and R 2 are joined to form a ring comprising —CH 2 (CH 2 ) n CH 2 — where n=0-5; —CH 2 CH 2 CMe 2 CH 2 CH 2 —; —O(CH 2 ) m CH 2 — where m=1-4; O(CH 2 ) p O— where p=1-4; —CH 2 CH 2 OCH 2 CH 2 —; —CH 2 CH 2 N(H or alkyl)CH 2 CH 2 —; or R 1 and R 2 together comprise a double bond to CMe 2 ; C(cycloalkyl), O, or C(cycloether); R 3 is H, OH, NH 2 , COR A ; or optionally substituted alkenyl or alkynyl groups; R A =H or optionally substituted alkyl, alkoxy, or aminoalkyl groups; R 4 =H, halo, CN, NH 2 , or optionally substituted alkyl, alkoxy, or aminoalkyl; R 5 is selected from optionally substituted benzene ring; a five or six membered heterocyclic ring; a 4 or 7-substituted indole or a substituted benzothiophene; or pharmaceutically acceptable salt thereof. These methods of treatment may be used for contraception or for the treatment and/or prevention of secondary amenorrhea, dysfunctional bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon, prostate, or mininization of side effects or cyclic menstrual bleeding. Additional uses of the invention include stimulation of food intake.

  本发明涉及使用取代的吲哚啉衍生物化合物的循环组合疗法和方案，它们是孕激素受体拮抗剂，具有以下一般结构：1其中：R1和R2分别选择自H、OH、OAc、烷基芳基、烷基杂芳基、1-丙炔基、3-丙炔基和可选取代烷基、O（烷基）、芳基或杂芳基基团；或R1和R2结合形成包含—CH2（ ）n —的环，其中n=0-5；— CMe2 —；—O（ ）m —其中m=1-4；O（ ）pO—其中p=1-4；— O —；— N（H或烷基） —；或R1和R2一起包括双键到CMe2；C（环烷基）、O或C（环乙醚）；R3为H、OH、NH2、CORA或可选取代的烯烃或炔烃基团；RA=H或可选取代的烷基、烷氧基或氨基烷基基团；R4=H、卤素、CN、NH2或可选取代的烷基、烷氧基或氨基烷基；R5选自可选取代的苯环、五元或六元杂环、4或7-取代吲哚或取代苯并噻吩；或其药学上可接受的盐。这些治疗方法可用于避孕或用于治疗和/或预防继发性闭经、功能性出血、子宫平滑肌瘤、子宫内膜异位症、多囊卵巢综合症、子宫内膜、卵巢、乳腺、结肠、前列腺的癌瘤和腺癌，或减少副作用或循环月经出血。本发明的其他用途包括促进食物摄入。
• Verfahren zur Herstellung von Hydrazinen
  申请人：BAYER AG

  公开号：EP0002721A2

  公开（公告）日：1979-07-11

  Hydrazine der Formel worin R einen Aryl- oder Aralkylrest und R einen Alkyl-, Aryl- oder Aralkylrest bedeuten, oder wenn R für einen Arylrest steht, R1 auch für einen Alkylen- oder Cycloalkylenrest stehen kann, der mit R in der ortho-Stellung zum Stickstoff verbunden ist, werden hergestellt, indem man sekundäre Amine der Formel zu Nitrosaminen umsetzt und diese ohne Isolierung bei 0 bis 50° C und bei pH-Werten von 5 bis 6 mit Zinkstaub in Gegenwart von Salzsäure oder Schwefelsäure reduziert und die Reduktion bei pH-Werten von unter 4 zu Ende führt.

  式中 R 为芳基或芳烷基，R 为烷基、芳基或芳烷基，或者如果 R 为芳基，R1 也可以是亚烷基或环亚烷基，该亚烷基或环亚烷基在氮的正交位置上与 R 连接，制备方法是将式中的仲胺与亚硝胺反应，然后在 0 至 50℃、pH 值为 5 至 6 的条件下，在盐酸或硫酸存在下用锌粉不经分离地还原这些亚硝胺，并在 pH 值低于 4 的条件下完成还原。
• FLUORESCENT DYE, PREPARATION METHOD THEREFOR AND USE THEREOF
  申请人：Shenzhen University

  公开号：EP3744810A1

  公开（公告）日：2020-12-02

  Disclosed are a fluorescent dye, a preparation method and an application thereof. The fluorescent dye has a general structural formula as shown in formula (I), wherein X and Y are same or different and selected from O, S, C(CH3)2 or NR6; R2 and R3 are the same or different and selected from hydrogen or a functional group; R1, R4, R5 and R6 are all functional groups; and Z- is a negative ion. The fluorescent dye has an ability to permeate the living cell membrane, so that it can be used in the fluorescence imaging of living cell microstructures, and can also be used in the STED super-resolution fluorescence imaging and laser scanning confocal microscopy of live cells.

  本发明公开了一种荧光染料及其制备方法和应用。该荧光染料的结构通式如式（I）所示，其中X和Y相同或不同，选自O、S、C(CH3)2或NR6；R2和R3相同或不同，选自氢或官能团；R1、R4、R5和R6均为官能团；Z-为负离子。该荧光染料具有渗透活细胞膜的能力，因此可用于活细胞微结构的荧光成像，也可用于活细胞的 STED 超分辨率荧光成像和激光扫描共聚焦显微镜。
• Fluorescent dye, preparation method therefor and use thereof
  申请人：Shenzhen University

  公开号：US10889719B2

  公开（公告）日：2021-01-12

  Disclosed are a fluorescent dye, a preparation method and an application thereof. The fluorescent dye has a structure of formula (I), where X and Y are independently selected from O, S, C(CH3)2 and NR6; R2 and R3 are independently hydrogen or a functional group; R1, R4, R5 and R6 are independently selected from functional groups; and Z− is a negative ion. The fluorescent dye has an ability to permeate the living cell membrane, so that it can be used in the fluorescence imaging of living cell microstructures, and can also be used in the STED super-resolution fluorescence imaging and laser scanning confocal microscopy of live cells.

  本发明公开了一种荧光染料及其制备方法和应用。该荧光染料具有式（I）结构，其中 X 和 Y 独立地选自 O、S、C(CH3)2 和 NR6；R2 和 R3 独立地为氢或官能团；R1、R4、R5 和 R6 独立地选自官能团；Z- 为负离子。该荧光染料具有渗透活细胞膜的能力，因此可用于活细胞微结构的荧光成像，也可用于活细胞的 STED 超分辨率荧光成像和激光扫描共聚焦显微镜。