[D-Dip2]AVP | 1160953-53-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [D-Dip2]AVP
• 英文别名: H-Cys(1)-D-Dip-Phe-Gln-Asn-Cys(1)-Pro-Arg-Gly-NH2；(2S)-1-[(4R,7S,10S,13S,16R,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-benzhydryl-13-benzyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
• CAS: 1160953-53-6
• 化学式: C₅₂H₆₉N₁₅O₁₁S₂
• 分子量: 1144.35
• InChiKey: QWCLNIWZFMOXIL-ZPYHCLEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  80
• 可旋转键数：
  20
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  494
• 氢给体数：
  13
• 氢受体数：
  15

反应信息

• 作为产物：
  描述：

  在 碘 、 溶剂黄146 作用下， 以 甲醇 、 乙醚 为溶剂， 生成 [D-Dip2]AVP
  参考文献：
  名称：

  Arginine vasopressin and its analogues – The influence of position 2 modification with 3,3-diphenylalanine enantiomers. Highly potent V2 agonists

  摘要：

  Eleven new analogues of arginine vasopressin (AVP) modified in position 2 by 3,3-diphenyl-L-alanine or its D-enantiomer (Dip or D-Dip) were synthesized and pharmacologically evaluated for their pressor, antidiuretic and in vitro uterotonic activities. Both the Dip and D-Dip modifications at position 2 of AVP are sufficient to completely change the pharmacological profile of the peptides. They preserve or increase antidiuretic activity, cause its prolongation, transform uterotonic property in antagonistic one and cancel the effect on blood pressure. Four of the new peptides ([Mpa(1),D-Dip(2)]AVP, [Mpa(1),D-Dip(2),Val(4)]AVP, [Mpa(1),D-Dip(2)-D-Arg(8)]VP, [Mpa(1),D-Dip(2),Val(4),D-Arg(8)]VP) are exceptionally potent antidiuretic agents with significantly prolonged activities. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.12.010