N-ethyl-4-t-butoxycarbonylaminobutanamide | 151363-16-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-ethyl-4-t-butoxycarbonylaminobutanamide
• 英文别名: (3-Ethylcarbamoyl-propyl)-carbamic acid tert-butyl ester；tert-butyl N-[4-(ethylamino)-4-oxobutyl]carbamate
• CAS: 151363-16-5
• 化学式: C₁₁H₂₂N₂O₃
• 分子量: 230.307
• InChiKey: NXWQORMQULRKIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-ethyl-4-t-butoxycarbonylaminobutanamide 在 盐酸 、 硼烷 作用下， 以 乙酸乙酯 为溶剂， 反应 264.5h， 生成 乙基去甲烟碱
  参考文献：
  名称：

  Formation of N′-ethyl-S-nornicotine by transformed root cultures of Nicotiana rustica

  摘要：

  N-Ethylputrescine dihydrochloride has been synthesized by an improved procedure and it is converted by transformed root cultures of Nicotiana rustica into the nicotine analogue, N'-ethyl-S-nornicotine, preferentially in the optically active S-form, with an efficiency similar to that of the corresponding natural process.

  DOI：

  10.1016/s0031-9422(00)90797-0
• 作为产物：
  描述：

  2-(叔丁氧羰基氧亚氨基)-2-苯乙腈 在 三乙胺 、 氯甲酸异丁酯 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 4.05h， 生成 N-ethyl-4-t-butoxycarbonylaminobutanamide
  参考文献：
  名称：

  Formation of N′-ethyl-S-nornicotine by transformed root cultures of Nicotiana rustica

  摘要：

  N-Ethylputrescine dihydrochloride has been synthesized by an improved procedure and it is converted by transformed root cultures of Nicotiana rustica into the nicotine analogue, N'-ethyl-S-nornicotine, preferentially in the optically active S-form, with an efficiency similar to that of the corresponding natural process.

  DOI：

  10.1016/s0031-9422(00)90797-0

文献信息

• Oligoamine compounds and derivatives thereof for cancer therapy
  申请人：SLIL Biomedical Corporation

  公开号：US20030130356A1

  公开（公告）日：2003-07-10

  Oligoamine compounds with anti-cancer and anti-proliferative activity are provided, as well as methods for making and using the compounds. The compounds are shown to be active against prostate cancer cell lines and against prostate cancer tumors in mice. The compounds are also useful in treatment of breast cancer and other cancers.

  提供具有抗癌和抗增殖活性的寡胺化合物，以及制备和使用这些化合物的方法。这些化合物已被证明对前列腺癌细胞系和小鼠前列腺癌肿瘤具有活性。这些化合物还在乳腺癌和其他癌症的治疗中具有用途。
• OLIGOAMINE COMPOUNDS AND DERIVATIVES THEREOF FOR CANCER THERAPY
  申请人：Frydman Benjamin

  公开号：US20090124832A1

  公开（公告）日：2009-05-14

  Oligoamine compounds with anti-cancer and anti-proliferative activity are provided, as well as methods for making and using the compounds. The compounds are shown to be active against prostate cancer cell lines and against prostate cancer tumors in mice. The compounds are also useful in treatment of breast cancer and other cancers.

  提供具有抗癌和抗增殖活性的寡胺化合物，以及制备和使用这些化合物的方法。这些化合物已被证明对前列腺癌细胞系和小鼠前列腺癌肿瘤具有活性。这些化合物还可用于治疗乳腺癌和其他癌症。
• US7491849B2
  申请人：——

  公开号：US7491849B2

  公开（公告）日：2009-02-17
• Formation of N′-ethyl-S-nornicotine by transformed root cultures of Nicotiana rustica
  作者：Henry D. Boswell、Allan B. Watson、Nicholas J. Walton、David J. Robins

  DOI：10.1016/s0031-9422(00)90797-0

  日期：1993.8

  N-Ethylputrescine dihydrochloride has been synthesized by an improved procedure and it is converted by transformed root cultures of Nicotiana rustica into the nicotine analogue, N'-ethyl-S-nornicotine, preferentially in the optically active S-form, with an efficiency similar to that of the corresponding natural process.