N-(3,4,6-tri-O-acetyl-2-fluoro-2-deoxy-β-D-glucopyranosyl)-2-(5-fluorouracil-1-yl)acetamide | 1313587-73-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(3,4,6-tri-O-acetyl-2-fluoro-2-deoxy-β-D-glucopyranosyl)-2-(5-fluorouracil-1-yl)acetamide
• 英文别名: [(2R,3R,4S,5R,6R)-3,4-diacetyloxy-5-fluoro-6-[[2-(5-fluoro-2,4-dioxopyrimidin-1-yl)acetyl]amino]oxan-2-yl]methyl acetate
• CAS: 1313587-73-3
• 化学式: C₁₈H₂₁F₂N₃O₁₀
• 分子量: 477.376
• InChiKey: MWIZOBQFICJIHA-WDGOXLLCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  167
• 氢给体数：
  2
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  3,4,6-Tri-O-acetyl-2-deoxy-2-fuoro-β-D-glucopyranosyl amine 、 2,4-二氧代-5-氟-3,4-二氢-1(2H)-嘧啶乙酸 在 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 以33%的产率得到N-(3,4,6-tri-O-acetyl-2-fluoro-2-deoxy-β-D-glucopyranosyl)-2-(5-fluorouracil-1-yl)acetamide
  参考文献：
  名称：

  Design, synthesis and in vitro drug release investigation of new potential 5-FU prodrugs

  摘要：

  In order to identify new efficient prodrugs of 5-fluorouracil (5-FU) and to develop an original targeting approach using 2-fluoro-2-deoxyglucose (FDG) as a potential drug carrier, eight original 5-FU derivatives were synthesized: 5-FU was attached by the N1 position of the pyrimidinic ring to the C1 position of the FDG structure either by direct coupling (2a) or via various spacers (3, 6a-c, 10b and 19). A new sensitive high-performance liquid chromatography method was developed to simultaneously quantify 5-FU and its derivatives in human plasma and other relevant media at physiological temperatures. Half-lives were determined from the degradation profiles of these conjugates. Slow degradation of compounds 2a, 3, 10b and 19 was observed in vitro at 37 degrees C, but no 5-FU release was noticed. By contrast, the in vitro drug release profiles of compounds 6a-c followed pseudo-first-order kinetics, and 5-FU was found in all the media. The antiproliferative activity of the eight compounds was assessed in vitro by a fluorometric assay against two human solid cancer cell lines and one healthy cell line. A correlation was found between the activities of the compounds and their ability to release 5-FU efficiently. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.04.010