2-[(S)-1-tert-Butoxycarbonyl-2-(2'-methoxy-biphenyl-4-yl)-ethylcarbamoyl]-tetrahydro-furan-2-carboxylic acid | 732299-75-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[(S)-1-tert-Butoxycarbonyl-2-(2'-methoxy-biphenyl-4-yl)-ethylcarbamoyl]-tetrahydro-furan-2-carboxylic acid
• CAS: 732299-75-1
• 化学式: C₂₆H₃₁NO₇
• 分子量: 469.535
• InChiKey: ZCCFTJYRAMQCKA-DQUNLGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.37
• 重原子数：
  34.0
• 可旋转键数：
  8.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  111.16
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  2-[(S)-1-tert-Butoxycarbonyl-2-(2'-methoxy-biphenyl-4-yl)-ethylcarbamoyl]-tetrahydro-furan-2-carboxylic acid 在 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 (S)-3-(2'-Methoxy-biphenyl-4-yl)-2-{[(S)-2-(morpholine-4-carbonyl)-tetrahydro-furan-2-carbonyl]-amino}-propionic acid
  参考文献：
  名称：

  Substituted tetrahydrofuroyl-1-phenylalanine derivatives as potent and specific VLA-4 antagonists

  摘要：

  A series of substituted tetra hydrofuroyl-1-phenylalanine derivatives was prepared and evaluated as VLA-4 antagonists. Substitution of the a carbon of the tetrahydrofuran with aryl groups increased the specificity for VLA-4 versus alpha(4)beta(7) while amide substitution increased the potency of the series without increasing the specificity. Substitution of the P carbon of the tetrahydrofuran with keto or amino groups slightly improved the specificity for VLA-4 versus alpha(4)beta(7) but with a significant loss in binding affinity for VLA-4. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00211-1
• 作为产物：
  描述：

  2-benzyloxycarbonyl-2-tetrahydrofuroic acid, methyl ester 在 palladium on activated charcoal sodium hydroxide 、 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 氢气 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 2-[(S)-1-tert-Butoxycarbonyl-2-(2'-methoxy-biphenyl-4-yl)-ethylcarbamoyl]-tetrahydro-furan-2-carboxylic acid
  参考文献：
  名称：

  Substituted tetrahydrofuroyl-1-phenylalanine derivatives as potent and specific VLA-4 antagonists

  摘要：

  A series of substituted tetra hydrofuroyl-1-phenylalanine derivatives was prepared and evaluated as VLA-4 antagonists. Substitution of the a carbon of the tetrahydrofuran with aryl groups increased the specificity for VLA-4 versus alpha(4)beta(7) while amide substitution increased the potency of the series without increasing the specificity. Substitution of the P carbon of the tetrahydrofuran with keto or amino groups slightly improved the specificity for VLA-4 versus alpha(4)beta(7) but with a significant loss in binding affinity for VLA-4. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00211-1