methyl (2S)-2-[(7-chloroquinolin-4-yl)amino]-4-methylpentanoate | 1285540-06-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2S)-2-[(7-chloroquinolin-4-yl)amino]-4-methylpentanoate
• CAS: 1285540-06-8
• 化学式: C₁₆H₁₉ClN₂O₂
• 分子量: 306.792
• InChiKey: CLVNJIMDWUZAMC-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  甲醇 、 以 溶剂黄146 为溶剂， 反应 0.33h， 以77%的产率得到methyl (2S)-2-[(7-chloroquinolin-4-yl)amino]-4-methylpentanoate
  参考文献：
  名称：

  A novel multicomponent reaction: easy access to ferrocenyl (alkylimino)-1,4-dihydroquinolines

  摘要：

  A facile and rapid synthetic approach of ferrocenyl (alkylimino)-1,4-dihydroquinolines through a novel multicomponent reaction is described. This strategy is high yielding (60-90%). The easy removal of the ferrocenyl entity led to formation of substituted quinolines by microwave method. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.144

文献信息

• A novel multicomponent reaction: easy access to ferrocenyl (alkylimino)-1,4-dihydroquinolines
  作者：Sylvain Pellegrini、Jean-Noël Grad、Till Bousquet、Lydie Pélinski

  DOI：10.1016/j.tetlet.2011.01.144

  日期：2011.4

  A facile and rapid synthetic approach of ferrocenyl (alkylimino)-1,4-dihydroquinolines through a novel multicomponent reaction is described. This strategy is high yielding (60-90%). The easy removal of the ferrocenyl entity led to formation of substituted quinolines by microwave method. (C) 2011 Elsevier Ltd. All rights reserved.