2-{4-oxo-1H,2H,4H-pyrazolo[3,4-d]pyrimidin-1-yl}acetic acid | 1311578-05-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-{4-oxo-1H,2H,4H-pyrazolo[3,4-d]pyrimidin-1-yl}acetic acid
• 英文别名: 2-(4-oxo-5H-pyrazolo[3,4-d]pyrimidin-1-yl)acetic acid
• CAS: 1311578-05-8
• 化学式: C₇H₆N₄O₃
• 分子量: 194.15
• InChiKey: CSTPQBYWSUAIOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  96.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Non-aggregating non-quenching oligomer comprising nucelotide analogs, method of synthesis and use thereof
  申请人：Epoch Biosciences, Inc.

  公开号：US20040116689A1

  公开（公告）日：2004-06-17

  The invention provides compositions and methods for improved hybridization analysis utilizing DNA, RNA, PNA and chimeric oligomers in which one or more purine bases are substituted by a pyrazolo[5,4-d]pyrimidine or by a 7-deazapurine purine analogue. Reduced self-aggregation and reduced fluorescence quenching are obtained when the oligomers are used in various methods involving hybridization. Methods of synthesis, as well as novel synthetic precursors, are also provided.

  本发明提供了一种利用DNA、RNA、PNA和嵌合寡核苷酸进行改进的杂交分析的组合物和方法，其中一个或多个嘌呤碱基被嘧唑并[5,4-d]嘧啶或7-脱氧嘌呤嘌呤类似物所替代。当这些寡核苷酸用于涉及杂交的各种方法时，可以获得减少自身聚集和减少荧光淬灭的效果。本发明还提供了合成方法以及新的合成前体。
• NON-AGGREGATING, NON-QUENCHING OLIGOMERS COMPRISING NUCLEOTIDE ANALOGUES; METHODS OF SYNTHESIS AND USE THEREOF
  申请人：Epoch Biosciences, Inc.

  公开号：EP1232157A2

  公开（公告）日：2002-08-21
• US6660845B1
  申请人：——

  公开号：US6660845B1

  公开（公告）日：2003-12-09
• US6972328B2
  申请人：——

  公开号：US6972328B2

  公开（公告）日：2005-12-06
• [EN] NON-AGGREGATING, NON-QUENCHING OLIGOMERS COMPRISING NUCLEOTIDE ANALOGUES; METHODS OF SYNTHESIS AND USE THEREOF<br/>[FR] OLIGOMERES DEPOURVUS D'AGREGATION ET D'EXTINCTION DE FLUORESCENCE COMPRENANT DES ANALOGUES DE NUCLEOTIDES; METHODES DE SYNTHESE ET UTILISATION CORRESPONDANTE
  申请人：EPOCH BIOSCIENCES INC

  公开号：WO2001038584A2

  公开（公告）日：2001-05-31

  The invention provides compositions and methods for improved hybridization analysis utilizing DNA, RNA, PNA and chimeric oligomers in which one or more purine bases are substituted by a pyrazolo[5,4-d]pyrimidine or by a 7-deazapurine purine analogue. Reduced self-aggregation and reduced fluorescence quenching are obtained when the oligomers are used in various methods involving hybridization. Methods of synthesis, as well as novel synthetic precursors, are also provided.