PAD-(NO2)6 | 1229038-28-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: PAD-(NO2)6
• CAS: 1229038-28-1
• 化学式: C₂₇H₁₅N₉O₁₅
• 分子量: 705.467
• InChiKey: YMMHKLJKAITBQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.89
• 重原子数：
  51.0
• 可旋转键数：
  12.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  346.14
• 氢给体数：
  3.0
• 氢受体数：
  15.0

反应信息

• 作为反应物：
  描述：

  PAD-(NO2)6 在 盐酸 、 tin 作用下， 以 乙醇 、 水 、 丙酮 为溶剂， 反应 20.5h， 生成
  参考文献：
  名称：

  Synthesis and characterization of polyamide metallodendrimers and their anti-bacterial and anti-tumor activities

  摘要：

  Pt(II) and Pd(II) complexes with aromatic amine terminated first generation (G(1)) and second generation (G(2)) polyamide dendrimers [PAD-(NH2) (n) ] (n = 6 for G(1) and 12 for G(2)) were synthesized. All the synthesized dendrimers and metallodenrimers were characterized by elemental and spectral analysis. These novel dendrimers and their metallodendrimers (metal complexes of dendrimers) were screened for their anti-bacterial activity against Bacillus subtilis and Staphylococcus aureus (Gram positive) and Escherichia coli and Salmonella typhi (Gram negative) using agar disk diffusion method. The cytotoxicity assay of the dendrimers and metallodendrimers has been performed against MFC-7 cell lines using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Anti-bacterial evaluation indicates that the second generation dendrimer exhibit stronger biological activity against all the pathogenic bacterial strains in comparison to the first generation dendrimers. PdG(2) exhibited lowest value of MIC 70 mu g/ml against E. coli, while MIC value of PtG(2) was 78 mu g/ml. PdG(2) and PtG(2) show lowest anti-bacterial activity against S. typhi with 102 and 110 mu g/ml (MIC value), respectively. In general, the metallodendrimers showed lower cytotoxicity than cisplatin (standard drug) and Pt(II) containing metallodendrimers were found to be more efficient in the induction of MFC-7 death than Pd(II) containing metallodendrimers.

  DOI：

  10.1007/s00044-011-9715-0
• 作为产物：
  描述：

  1,3,5-苯三甲酰氯 、 3,5-二硝基苯胺 反应 6.0h， 以70%的产率得到PAD-(NO2)6
  参考文献：
  名称：

  Synthesis and characterization of polyamide metallodendrimers and their anti-bacterial and anti-tumor activities

  摘要：

  Pt(II) and Pd(II) complexes with aromatic amine terminated first generation (G(1)) and second generation (G(2)) polyamide dendrimers [PAD-(NH2) (n) ] (n = 6 for G(1) and 12 for G(2)) were synthesized. All the synthesized dendrimers and metallodenrimers were characterized by elemental and spectral analysis. These novel dendrimers and their metallodendrimers (metal complexes of dendrimers) were screened for their anti-bacterial activity against Bacillus subtilis and Staphylococcus aureus (Gram positive) and Escherichia coli and Salmonella typhi (Gram negative) using agar disk diffusion method. The cytotoxicity assay of the dendrimers and metallodendrimers has been performed against MFC-7 cell lines using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Anti-bacterial evaluation indicates that the second generation dendrimer exhibit stronger biological activity against all the pathogenic bacterial strains in comparison to the first generation dendrimers. PdG(2) exhibited lowest value of MIC 70 mu g/ml against E. coli, while MIC value of PtG(2) was 78 mu g/ml. PdG(2) and PtG(2) show lowest anti-bacterial activity against S. typhi with 102 and 110 mu g/ml (MIC value), respectively. In general, the metallodendrimers showed lower cytotoxicity than cisplatin (standard drug) and Pt(II) containing metallodendrimers were found to be more efficient in the induction of MFC-7 death than Pd(II) containing metallodendrimers.

  DOI：

  10.1007/s00044-011-9715-0

文献信息

• Synthesis Characterization of Polyamide Metallodendrimers and their Catalytic Activities in Ethylene Oligomerization
  作者：Tansir Ahamad、Saad M. Alshehri、S. F. Mapolie

  DOI：10.1007/s10562-010-0393-1

  日期：2010.9

  Nickel complexes with aromatic amine terminated first generation (G1) and second generation (G2) polyamide dendrimers POA-(NH2)(n) (n = 6 or 12, POM = Polyamide)} were synthesized. All the synthesized dendrimers and metallodendrimers were characterized by elemental and spectral analysis. These novel dendritic complexes were evaluated as catalyst precursors in the oligomerization of ethylene, using methylaluminoxane (MAO) as an activator at two different pressure and different Al/M (M = Zn) ratio. In the case of 1 atm pressure of ethylene, and 500:1 and 1,000:1 Al/Ni molar ratio, for C (1) and C (2) respectively display higher catalytic activity towards ethylene polymerization. Oligomerization using the generation 1 dendrimer complex, C (1) yields short chain oligomers whereas those obtained from the generation 2 dendrimer catalyst, C (2) resulted in longer chain products with molecular weights up to 9.54 x 10(4) and 9.86 x 10(4) g/mol at 1 and 5 atm respectively.Two new Nickel metallodendrimers C (1) and C (2) were evaluated as catalysts precursor in the polymerization of ethylene using methylaluminooxane (MOA) as co-catalyst at two different pressure and different Al/M (M = Zn) ratio. Both catalysts evaluated were found to be active for ethylene oligomerization giving polymers and higher molecular weight products.