4-propagyl-2-phenyl-2-oxazoline-4-carboxylic acid methyl ester | 1195159-20-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-propagyl-2-phenyl-2-oxazoline-4-carboxylic acid methyl ester
• 英文别名: methyl 2-phenyl-4-prop-2-ynyl-5H-1,3-oxazole-4-carboxylate
• CAS: 1195159-20-6
• 化学式: C₁₄H₁₃NO₃
• 分子量: 243.262
• InChiKey: MBGJKPNESMTMFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  47.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  甲醇 、 methyl 4-(naphthalen-2-ylmethyl)-2-phenyl-5H-1,3-oxazole-4-carboxylate 在 sodium methylate 作用下， 反应 6.0h， 以20 mg的产率得到4-propagyl-2-phenyl-2-oxazoline-4-carboxylic acid methyl ester
  参考文献：
  名称：

  Solid-phase synthesis of α-alkylserines via phase-transfer catalytic alkylation of polymer-supported 2-phenyl-2-oxazoline-4-carboxylate

  摘要：

  Described is the development of a new solid-phase synthetic method for alpha-alkylserines in which phase-transfer catalytic alkylation of polymer-supported 2-phenyl-2-oxazoline-4-carboxylate (12) is the key step. The easy preparation of the polymer-supported substrate 12, the high chemical yield (up to 93%), and the mild cleavage conditions could make this method very practical for the synthesis of a-alkylserines. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.08.052

文献信息

• Solid-phase synthesis of α-alkylserines via phase-transfer catalytic alkylation of polymer-supported 2-phenyl-2-oxazoline-4-carboxylate
  作者：Jihye Lee、Min Woo Ha、Taek-Soo Kim、Mi-Jeong Kim、Jin-Mo Ku、Sang-sup Jew、Hyeung-geun Park、Byeong-Seon Jeong

  DOI：10.1016/j.tet.2009.08.052

  日期：2009.10

  Described is the development of a new solid-phase synthetic method for alpha-alkylserines in which phase-transfer catalytic alkylation of polymer-supported 2-phenyl-2-oxazoline-4-carboxylate (12) is the key step. The easy preparation of the polymer-supported substrate 12, the high chemical yield (up to 93%), and the mild cleavage conditions could make this method very practical for the synthesis of a-alkylserines. (c) 2009 Elsevier Ltd. All rights reserved.