1-[(3aR,4R,6R,6aR)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methoxy-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-6-(1,3-diphenyl-imidazolidin-2-yl)-1H-pyrimidine-2,4-dione | 380883-23-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1-[(3aR,4R,6R,6aR)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methoxy-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-6-(1,3-diphenyl-imidazolidin-2-yl)-1H-pyrimidine-2,4-dione
• 英文别名: 1-[(3aR,4R,6R,6aR)-6-[[tert-butyl(dimethyl)silyl]oxymethyl]-2-methoxy-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-6-(1,3-diphenylimidazolidin-2-yl)pyrimidine-2,4-dione
• CAS: 380883-23-8
• 化学式: C₃₂H₄₂N₄O₇Si
• 分子量: 622.794
• InChiKey: ZCFOMVIJVHZWFW-PINHWGBQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  44.0
• 可旋转键数：
  8.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  107.49
• 氢给体数：
  1.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  1-[(3aR,4R,6R,6aR)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methoxy-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-6-(1,3-diphenyl-imidazolidin-2-yl)-1H-pyrimidine-2,4-dione 在 磷酸三乙酯 、 四丁基氟化铵 、 三氯氧磷 作用下， 以 四氢呋喃 为溶剂， 生成 6-formyluridine 5'-monophosphate ammonium salt
  参考文献：
  名称：

  SYNTHESIS OF 6-FORMYLURIDINE 5′-MONOPHOSPHATE: 6-FORMYL-UMP

  摘要：

  A synthesis of 6-formyluridine 5'-monophosphate (6-formylUMP) in 6 steps starting from uridine is described. This approach should be applicable to the preparation of other O5'-phosphorylated 6-formylUrds such as 6-formylUDP and 6-formylUTP.

  DOI：

  10.1081/ncn-100002478
• 作为产物：
  描述：

  尿嘧啶核苷 在 对甲苯磺酸 lithium diisopropyl amide 作用下， 以 甲苯 为溶剂， 生成 1-[(3aR,4R,6R,6aR)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methoxy-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-6-(1,3-diphenyl-imidazolidin-2-yl)-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  SYNTHESIS OF 6-FORMYLURIDINE 5′-MONOPHOSPHATE: 6-FORMYL-UMP

  摘要：

  A synthesis of 6-formyluridine 5'-monophosphate (6-formylUMP) in 6 steps starting from uridine is described. This approach should be applicable to the preparation of other O5'-phosphorylated 6-formylUrds such as 6-formylUDP and 6-formylUTP.

  DOI：

  10.1081/ncn-100002478