(1S,2S,4aS,4bS,8R,8aS,10aS)-8-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-2-hydroxy-1,4a-dimethyl-6,9-dioxo-1,2,3,4,4b,5,7,8,10,10a-decahydrophenanthrene-8a-carbaldehyde | 1207384-18-6

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: (1S,2S,4aS,4bS,8R,8aS,10aS)-8-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-2-hydroxy-1,4a-dimethyl-6,9-dioxo-1,2,3,4,4b,5,7,8,10,10a-decahydrophenanthrene-8a-carbaldehyde
• CAS: 1207384-18-6
• 化学式: C₂₅H₄₂O₅Si
• 分子量: 450.691
• InChiKey: SPLBNILZDOXKHH-USMYAQTDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.57
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  80.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (1S,2S,4aS,4bS,8R,8aS,10aS)-2-(benzyloxy)-8-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1,4a-dimethyl-6,9-dioxododecahydrophenanthrene-8a(2H)-carbaldehyde 在 palladium 10% on activated carbon 、 氢气 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以65%的产率得到(1S,2S,4aS,4bS,8R,8aS,10aS)-8-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-2-hydroxy-1,4a-dimethyl-6,9-dioxo-1,2,3,4,4b,5,7,8,10,10a-decahydrophenanthrene-8a-carbaldehyde
  参考文献：
  名称：

  Versatile Strategy to Access Tricycles Related to Quassinoids and Triterpenes

  摘要：

  The reactivity of two new bicyclic cyclohexenones (13 and 27) with several Nazarov reagents is presented. A flexible synthetic strategy is developed and provides access to highly substituted tricycles related to quassinoids and triterpenes.

  DOI：

  10.1021/ol902711b