| 34897-55-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 34897-55-7
• 化学式: C₂₅H₃₆N₂O₉
• 分子量: 508.569
• InChiKey: OJWACLPGLSSNBT-ROUUACIJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  36.0
• 可旋转键数：
  10.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  146.33
• 氢给体数：
  2.0
• 氢受体数：
  9.0

反应信息

• 作为产物：
  描述：

  (S)-2-benzyloxycarbonylamino-succinic acid 1-tert-butyl ester 、 (S)-1-叔丁基-4-甲基-2-氨基丁二酸盐 在 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  CD Spectra in Methanol ofβ-Oligopeptides Consisting ofβ-Amino Acids with Functionalized Side Chains, with Alternating Configuration, and with Geminal Backbone Substituents - Fingerprints of New Secondary Structures?

  摘要：

  beta -Hexa-, beta -hepta-, and beta -nonapeptides, 1-6, which carry functionalized side chains (CO(2)R, CO(2)(-), (CH(2))(4)NH(3)(+), CH(2)-CH=CH(2)) consisting of beta (3)-amino-acid residues of alternating configuration, or which carry geminal substituents in the 2- or 3-positions of all residues, have been synthesized (Schemes 1 - 3), and their CD spectra in MeOH are reported (Figs. 2 - 6). Strong Cotton effects (Theta >10(5)) are indicative of the presence of chiral secondary structures. It is suggested by simple modelling (Fig. 1) that the new beta -peptides should not be able to fold to the familiar 3(14)-helical structures. Still, three of them (3, 4, and 5) give rise to CD spectra matching those of beta -peptides that are known to be present as (M)- or (P)3(14)-helices in MeOH solution. While possible folding motifs (Figs. 3, b, and 7) of the new beta -peptides have been identified in crystal structures, an interpretation of the CD spectra has to be postponed until NMR solution structures become available. A list of all beta -peptides giving rise to CD spectra with a minimum near 215 nm is included (Table).

  DOI：

  10.1002/1522-2675(20001108)83:11<2849::aid-hlca2849>3.0.co;2-r

文献信息

• Polypeptides. Part XVIII. Syntheses of poly-(β-aspartic acid) and poly-(γ-glutamic acid) and their benzyl esters
  作者：P. M. Hardy、J. C. Haylock、H. N. Rydon

  DOI：10.1039/p19720000605

  日期：——

  L-aspartate) has been prepared by the polymerisation of α-benzyl β-N-succinimidyl L-aspartate and converted into poly-(β-L-aspartic acid) by hydrogenolysis; treatment of the poly(benzyl ester) with hydrogen bromide in acetic acid leads to a different polymer containing a substantial proportion of aspartimide residues. The analogous route cannot be used for the preparation of poly-(α-benzyl L-glutamate)

  聚（α -苄基大号天冬氨酸）已被制备α -苄基β-的聚合Ñ琥珀酰亚胺大号天冬氨酸和转化成聚- （β-大号通过氢解-天冬氨酸）; 在乙酸中用溴化氢对聚（苄基酯）进行处理可得到一种含有大量比例的天冬酰胺残基的不同聚合物。类似的方法不能用于制备聚-（α-苄基L-谷氨酸），最好通过αα'-二苄基γ- N-琥珀酰亚胺基γ - L-谷氨酰基-L-谷氨酸的聚合来制备。由聚（α-苄基L）获得聚（γ- L-谷氨酸）-谷氨酸盐）通过溴化氢在乙酸中的作用。多元酸的分子量为约11,000，并且没有消旋化伴随聚合。