丙交酯-己内酯共聚物 | 70524-20-8

• 物质功能分类: 催化剂及助剂 - 聚合物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 中文名称: 丙交酯-己内酯共聚物
• 中文别名: 1-(2-环己基-2-羰基乙基)-5-甲氧基-2-甲基-1H-吲哚-3-乙酸
• 英文名称: Lactide-caprolactone coploymer
• 英文别名: 3,6-dimethyl-1,4-dioxane-2,5-dione;oxepan-2-one
• CAS: 70524-20-8
• 化学式: C12H18O6
• 分子量: 258.27
• InChiKey: ZAJGKKXBKLVSKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.97
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3,6-二甲基-1,4-二氧杂环己烷-2,5-二酮 、 6-己内酯 在 锡 、 十二烷醇 作用下， 反应 30.0h， 以A total of 96.7 grams of the viscous liquid polymer was obtained的产率得到丙交酯-己内酯共聚物
  参考文献：
  名称：

  Low viscosity liquid polymeric delivery system

  摘要：

  提供了一种低粘度的可生物降解聚合物溶液，包括液态可生物降解聚合物和生物相容性溶剂，并提供使用这些组合物形成可生物降解液态聚合物植入物的方法。

  公开号：

  US08187640B2
• 作为试剂：
  描述：

  Tin2-ethylhexanoate 、 L-丙交酯 、 6-己内酯 、 在 丙交酯-己内酯共聚物 作用下， 反应 16.0h， 生成 丙交酯-己内酯共聚物
  参考文献：
  名称：

  Adhesion-Preventive Film

  摘要：

  提供一种优秀的柔韧性、可以防止裂纹发生的防粘膜。该防粘膜含有乳酸内酯和己内酯的共聚物。该共聚物的乳酸内酯和己内酯的摩尔比在65：35至80：20的范围内。即使在体内呈弯曲状态或缠绕在受影响的部位（例如腱）周围时，该防粘膜也可以提供足够长时间的防粘功能，而不会出现裂纹。

  公开号：

  US20080090936A1

文献信息

• Polymorph Compositions, Methods of Making, and Uses Thereof
  申请人：Macdonald R. Loch

  公开号：US20130302431A1

  公开（公告）日：2013-11-14

  The described invention provides a biodegradable, biocompatible delivery system of flowable sustained release microparticulate composition of a substantially pure crystalline form of a bioactive agent such as, for example, nimodipine, a process of preparing a therapeutic form of a substantially pure crystalline form of the bioactive agent and a method for treating an interruption of a cerebral artery in a subarachnoid space at risk of interruption caused by brain injury in a mammal, which reduces signs or symptoms of at least one delayed complication associated with brain injury.

  所述发明提供了一种可生物降解、生物相容的流动持续释放微粒组合物的输送系统，其包含一种基本纯的晶体形式的生物活性剂，例如尼莫地平，以及一种制备基本纯的晶体形式生物活性剂的治疗形式的过程，以及一种治疗哺乳动物脑损伤引起的潜在中断的蛛网膜下腔脑动脉中断的方法，该方法减少与脑损伤相关的至少一种延迟并发症的症状或体征。
• DRUG-ELUTING MEDICAL DEVICES
  申请人：Zilberman Meital

  公开号：US20110091515A1

  公开（公告）日：2011-04-21

  Composite structures composed of a device as a core structure, being a medical device or article, and a porous polymeric coat and designed capable of encapsulating bioactive agents while retaining the activity of these agents are disclosed. Further disclosed are processes of preparing such composite structures.

  本发明涉及一种由设备作为核心结构、该设备可以是医疗器械或物品，以及多孔聚合物涂层组成的复合结构，该复合结构设计能够封装生物活性剂并保持这些剂的活性。进一步揭示了制备这种复合结构的过程。
• Perivascular wraps
  申请人：Gravett M David

  公开号：US20080085855A1

  公开（公告）日：2008-04-10

  The present invention provides compositions, devices, and methods for maintaining or improving the integrity of body passageways following surgery, such as at a graft site, or injury. Delivery devices including one or more therapeutic agents and a mesh are described. Representative examples of therapeutic agents include microtubule stabilizing agents, anti-angiogenic factors, inhibitors of smooth muscle cell growth or proliferation, non-steroidal anti-inflammatory drugs, and other factors useful preventing and/or reducing a proliferative biological response that may obstruct or hinder the optimal functioning of the passageway or cavity.

  本发明提供了维持或改善手术后身体通道完整性的组合物、装置和方法，例如在移植部位或受伤处。描述了包括一个或多个治疗剂和网状物的输送装置。治疗剂的代表性例子包括微管稳定剂、抗血管生成因子、平滑肌细胞生长或增殖抑制剂、非甾体抗炎药和其他有用的因子，用于预防和/或减少可能阻碍或妨碍通道或腔体的最佳功能的增殖生物反应。
• COMPOSITIONS AND METHODS FOR POTENTIATED ACTIVITY OF BIOLOGICALLY ACTIVE MOLECULES
  申请人：Jadhav Vasant

  公开号：US20100015218A1

  公开（公告）日：2010-01-21

  The present invention relates to novel compositions and methods for potentiating the activity of biologically active molecules in conjunction with one or more delivery vehicles and one or more carrier molecules. Specifically, the invention features the use of a carrier molecule in combination with a delivery vehicle and a biologically active molecule of interest to potentiate the activity of the biologically active molecule. The carrier molecule can be biologically inert, inactive, or attenuated; or can alternately be biologically active in the same or different manner than the biologically active molecule of interest. Specifically, the invention features novel particle forming delivery agents including cationic lipids, microparticles, and nanoparticles that are useful for delivering various biologically active molecules to cells in conjunction with a carrier molecule. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism that are delivered intracellularly in conjunction with a carrier molecule. In various embodiments, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.), cholesterol, hormones, antivirals, peptides, proteins, chemotherapeutics, small molecules, vitamins, co-factors, nucleosides, nucleotides, oligonucleotides, enzymatic nucleic acids, antisense nucleic acids, triplex forming oligonucleotides, 2,5-A chimeras, allozymes, aptamers, decoys and analogs thereof, and small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules, to relevant cells and/or tissues, such as in a subject or organism, in conjunction with one or more carrier molecules. Such novel cationic lipids, microparticles, nanoparticles and transfection agents that are used in conjunction with one or more carrier molecules are useful, for example, in providing compositions to prevent, inhibit, or treat diseases, conditions, or traits in a cell, subject or organism.

  本发明涉及一种新型组合物和方法，用于增强生物活性分子的活性，结合一个或多个传递载体和一个或多个载体分子。具体而言，本发明涉及使用载体分子与传递载体和感兴趣的生物活性分子结合，以增强生物活性分子的活性。载体分子可以是生物惰性、不活跃或减弱的；或者可以是与生物活性分子以相同或不同的方式活跃的。具体而言，本发明涉及新型形成颗粒的传递剂，包括阳离子脂质、微粒和纳米粒子，它们对于传递各种生物活性分子到细胞中与载体分子结合是有用的。本发明还涉及组合物和使用方法，用于研究、诊断和治疗在主体或有机体中对基因表达和/或活性调节有反应的特征、疾病和情况，这些组合物和方法是与载体分子一起递送到细胞内的。在各种实施例中，本发明涉及新型阳离子脂质、微粒、纳米粒子和转染剂，它们有效地转染或递送生物活性分子，如抗体（例如单克隆、嵌合、人源化等）、胆固醇、激素、抗病毒药物、肽、蛋白质、化学治疗药物、小分子、维生素、辅因子、核苷、核苷酸、寡核苷酸、酶核酸、反义核酸、三链体寡核苷酸、2,5-A嵌合体、异构酶、适配体、诱饵和其类似物以及小核酸分子，如短干扰核酸（siNA）、短干扰RNA（siRNA）、双链RNA（dsRNA）、微RNA（miRNA）和短发夹RNA（shRNA）分子，递送到相关的细胞和/或组织中，例如在主体或有机体中，与一个或多个载体分子结合。这种与一个或多个载体分子一起使用的新型阳离子脂质、微粒、纳米粒子和转染剂是有用的，例如提供组合物以预防、抑制或治疗细胞、主体或有机体中的疾病、情况或特征。
• Biodegradable multi-block co-polymers
  申请人：Hissink Everdina Catharina

  公开号：US20070155906A1

  公开（公告）日：2007-07-05

  The invention relates to a biodegradable multi-block copolymer, comprising at least two hydrolysable segments derived from pre-polymers A and B, which segments are linked by a multi-functional chain-extender and are chosen from the pre-polymers A and B, and triblock copolymers ABA and BAB, wherein the multi-block copolymer is amorphous at physiological (body) conditions. The invention further relates to a process for preparing said copolymer and to its use as a medical implant, a coating for a medical device or a drug delivery vehicle.

  该发明涉及一种可生物降解的多段嵌段共聚物，包括至少两个可水解的片段，这些片段来自预聚物A和B，这些片段由多功能链延伸剂连接，并且选择自预聚物A和B，以及三嵌段共聚物ABA和BAB，其中多段嵌段共聚物在生理（体内）条件下是无定形的。该发明还涉及制备该共聚物的方法以及其用作医疗植入物、医疗设备涂层或药物输送载体的用途。