5-methoxy-2-methyl-3-(2-nitro-1-phenylethyl)-1H-indole | 1227380-56-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-methoxy-2-methyl-3-(2-nitro-1-phenylethyl)-1H-indole
• CAS: 1227380-56-4
• 化学式: C₁₈H₁₈N₂O₃
• 分子量: 310.353
• InChiKey: CHNJFGXDHDYTRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.89
• 重原子数：
  23.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  68.16
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  5-甲氧基-2-甲基吲哚 、 反式硝基苯乙烯 在 C₄H₃O₅^(3-)*C₁₂H₈N₅^(1-)*4.5H₂O*2Co⁽²⁺⁾ 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以70%的产率得到5-methoxy-2-methyl-3-(2-nitro-1-phenylethyl)-1H-indole
  参考文献：
  名称：

  在叠氮化物-炔烃环加成反应和Friedel-Crafts反应以及炔烃的氢化硅烷化中具有强大的多相Co-MOF催化剂

  摘要：

  考虑到它们的环保特性和潜在的催化剂可回收性，使用金属-有机骨架（MOFs）作为催化剂的有机反应很有希望。一个强大的Co（II）-MOF {[CO 2（大号-mac）（4,4- BPT）（H 2 O）]·3.5H 2 ö} Ñ（1）及其对映体{[CO 2（d - mac）（4,4-bpt）（H 2 O）]·3.5H 2 O} n（2）（L / D -mac = L / D-苹果酸的基本形式，4,4-Hbpt = 3， 5-二（吡啶-4-基）-4 H-1,2,4-三唑）已在溶剂热条件下克级制备。结构分析表明，mac管理Co（II）离子以形成1-D链，该链通过4,4-bpt连接器进一步扩展为非互穿3D框架体系结构。发现1可以作为多种有机反应的非均相催化剂，例如叠氮化物-炔烃环加成反应和Friedel-Crafts反应，具有良好的分离收率和良好的循环运行性能（至少5次没有实质性降解）。另外，1可以

  DOI：

  10.1039/d0nj04626d

文献信息

• A base-free copper-assisted synthesis of <i>C</i>₂-symmetric spirotelluranes and biaryls based on divergent stoichiometry of Na₂Te
  作者：Monojit Batabyal、Saket Jain、Aditya Upadhyay、Saravanan Raju、Sangit Kumar

  DOI：10.1039/d2cc02181a

  日期：——

  methodology has been developed for the preparation of biologically important C2-symmetric spirodiaza, benzyloxy and benzoxytelluranes from 2-bromo-N-aryl benzamides, benzyl alcohols, and benzoic acids by using the tellurium dianion (Te2−) under base-free conditions. Furthermore, C–C coupled biaryl 1,1′-diamides have been prepared by using an excess of Na2Te under the same reaction conditions. The synthesized

  已经开发了一种一锅法 Cu( I ) 辅助合成方法，用于通过使用碲双阴离子从 2-溴-N-芳基苯甲酰胺、苯甲醇和苯甲酸制备具有生物学重要意义的C 2 -对称螺二氮杂、苯甲氧基和苯甲氧基碲烷。 (Te 2- ) 在无碱条件下。此外，在相同的反应条件下，通过使用过量的 Na 2 Te 制备了 C-C 偶联联芳基 1,1'-二酰胺。合成的螺二氮杂碲烷可作为还原 H 2 O 2和硝基-迈克尔反应的有效催化剂。
• Bottom-Up Assembly of a Highly Efficient Metal–Organic Framework for Cooperative Catalysis
  作者：Changda Li、Haitong Tang、Yu Fang、Zhifeng Xiao、Kunyu Wang、Xiang Wu、Helin Niu、Chengfeng Zhu、Hong-cai Zhou

  DOI：10.1021/acs.inorgchem.8b02434

  日期：2018.11.5

  In this study, we demonstrate a bottom-up assembly of a monomeric copper complex and a two-dimensional (2-D) heterometallic metal-organic framework (MOF) from a carboxylate-functionalized tridentate Schiff base ligand and metal ions. The obtained 2-D MOF features a unique bimetallic copper center which is different from its monometallic precursor and acts as an efficient heterogeneous catalyst for the Friedel-Crafts reaction and Henry reaction. The MOF catalyst shows a remarkably superior activity compared to its homogeneous counterparts in a wide range of substrates. It is presumably ascribed to the dual activation of the substrates by the active bimetallic copper center confined in the MOF network, which is supported by the significant changes in catalytic activity at low catalyst/substrates ratios when using the 2-D MOF and its precursor as catalysts, respectively. Moreover, the MOF catalyst also shows an excellent stability and recyclability. Our work, therefore, provides a stepwise strategy to design a heterogeneous cooperative catalyst, by taking advantage of the modulated structure of MOF and tunable functionality of the tridentate Schiff base, with high performance in a variety of organic synthesis.
• A combination of water and microwave irradiation promotes the catalyst-free addition of pyrroles and indoles to nitroalkenes
  作者：Margherita De Rosa、Annunziata Soriente

  DOI：10.1016/j.tet.2010.02.055

  日期：2010.4

  A combination of water and microwave irradiation was used for the first time to perform a catalyst-free nitro-Michael addition of pyrroles and indoles. Under superheated conditions, the water trends to ionize by changing its chemical and physical properties. Therefore, we performed a new green-protocol using the water either as environmentally no harm solvent or as catalyst. The reaction success is independent from the kind of pyrrole, indole or nitroalkenes rapidly affording the corresponding adducts and giving excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.