4-氰基-4-[(2-苯乙基)硫代]硫氧甲基]硫代]-戊酸 | 1351859-46-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 4-氰基-4-[(2-苯乙基)硫代]硫氧甲基]硫代]-戊酸
• 英文名称: 4-cyano-4-((2-phenylethylsulfanylthiocarbonyl)sulfanyl)pentanoic acid
• 英文别名: 4-cyano-4-(2-phenylethanesulfanylthiocarbonyl)sulfanylpentanoic acid；PETTC；4-Cyano-4-(((phenethylthio)carbonothioyl)thio)pentanoic acid；4-cyano-4-(2-phenylethylsulfanylcarbothioylsulfanyl)pentanoic acid
• CAS: 1351859-46-5
• 化学式: C₁₅H₁₇NO₂S₃
• 分子量: 339.503
• InChiKey: HIUNIOPNZSEESZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  144
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-苯乙硫醇 在 碘 、 sodium hydride 作用下， 以 乙醚 、 乙酸乙酯 、 mineral oil 为溶剂， 反应 20.17h， 生成 4-氰基-4-[(2-苯乙基)硫代]硫氧甲基]硫代]-戊酸
  参考文献：
  名称：

  通过RAFT水性分散聚合制备的稳定的阴离子型聚电解质纳米粒子

  摘要：

  我们报告了通过使用RAFT水性分散聚合配方的聚合反应诱导的自组装，合成了阴离子空间稳定的二嵌段共聚物纳米粒子。阴离子型空间稳定剂是基于聚甲基丙烯酸3-磺基丙基钾（PKSPMA）的大分子链转移剂（macro-CTA），疏水性成核嵌段基于聚甲基丙烯酸2-（羟丙基）酯（PHPMA） 。研究了各种合成参数（如盐浓度，固体含量，相对嵌段组成和阴离子电荷密度）的影响。在没有盐的情况下，使用PKSPMA稳定剂时，自组装会出现问题，因为高电荷阴离子链之间会发生侧向排斥。然而，在存在添加盐的情况下，可以通过以下方式解决此问题：（i）统计地将KSPMA单体与非离子型共聚单体（甲基丙烯酸2-羟乙酯，HEMA）进行共聚；或（ii）使用二元共聚物PKSPMA大号CTA和聚（甲基丙烯酸单甘油酯）（PGMA）大号CTA的混合物。这些二嵌段共聚物纳米粒子通过1 H NMR光谱，凝胶渗透色谱（GPC），动态光散射（DLS）

  DOI：

  10.1021/la203991y

文献信息

• Cationic Polyelectrolyte-Stabilized Nanoparticles via RAFT Aqueous Dispersion Polymerization
  作者：M. Semsarilar、V. Ladmiral、A. Blanazs、S. P. Armes

  DOI：10.1021/la304279y

  日期：2013.6.18

  copolymerizing QDMA monomer with a nonionic comonomer (e.g., glycerol monomethacrylate, GMA) or (ii) using a binary mixture of a PQDMA macro-CTA and a poly(glycerol monomethacrylate) (PGMA) macro-CTA. These cationic diblock copolymer nanoparticles were analyzed by 1H NMR spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM), and aqueous electrophoresis. NMR studies suggest that

  我们报告了使用RAFT水性分散聚合配方通过聚合诱导的自组装（PISA）合成阳离子空间稳定的二嵌段共聚物纳米粒子。阳离子空间稳定剂是基于季铵化的聚甲基丙烯酸2-（二甲基氨基）乙酯（PQDMA）的大分子链转移剂（MAcro-CTA），疏水性成核嵌段基于聚甲基丙烯酸2-（羟丙基）酯（PHPMA）。研究了各种合成参数（如盐浓度，固体含量，相对嵌段组成和阳离子电荷密度）的影响。在没有盐的情况下，由于高度阳离子的PQDMA稳定剂链之间的排斥力强，因此自组装会遇到问题。然而，在存在盐的情况下，可以通过以下方式解决此问题：（i）将QDMA单体与非离子型共聚单体（例如，单甲基丙烯酸甘油酯，GMA）进行统计共聚，或（ii）使用PQDMA宏CTA和聚（甲基丙烯酸单甘油酯）（PGMA）宏CTA。这些阳离子二嵌段共聚物纳米粒子通过1 H NMR光谱，动态光散射（DLS），透射电子显微镜（TEM）和水性电泳。NMR研
• Efficient Synthesis of Amine-Functional Diblock Copolymer Nanoparticles via RAFT Dispersion Polymerization of Benzyl Methacrylate in Alcoholic Media
  作者：Elizabeth R. Jones、Mona Semsarilar、Adam Blanazs、Steven P. Armes

  DOI：10.1021/ma300898e

  日期：2012.6.26

  Benzyl methacrylate (BzMA) is Polymerized via reversible addition fragmentation chain transfer (RAFT) chemistry under alcoholic dispersion polymerization conditions in ethanol using a poly(2-(dimethylamino)ethyl methacrylate) (PDMA) chain transfer agent (CTA) at 70 degrees C. In principle, polymerization-induced self-assembly can lead to the formation of either spherical, micelles, wormlike micelles, or vesicles, with the preferred morphology being dictated by the hydrophilic hydrophobic balance Of the PDMA PBzMA diblock copolymer chains. Very high monomer conversions (>99%) are routinely obtained within 24 h as judged by H-1 NMR studies. Moreover, THF GPC analyses confirmed that relatively low polydispersities (M-w/M-n < 1.30) are achieved, indicating reasonably good pseudoliving character. A detailed phase diagram was constructed using a PDMA(31) macro-CTA by systematically varying both the target degree of polymerization of the PBzMA block and the total solids concentration of the reaction solution. This phase diagram can be used to reliably predict the synthesis conditions required to produce pure phases, rather than merely mixed phases (e.g., spheres plus worms or worms plus vesicles). Finally, these PDMA-PBzMA diblock copolymer nanoparticles remain colloidally stable when transferred from ethanol into water; aqueous electrophoresis studies confirmed that the particles acquire appreciable cationic character below pH 7 due to protonation of the PDMA stabilizer chains.
• METHODS OF SYNTHESIS OF HOMOPOLYMERS AND NON-HOMOPOLYMERS COMPRISING REPEATING UNITS DERIVED FROM MONOMERS COMPRISING LACTAM AND ACRYLOYL MOIETIES IN AN AQUEOUS MEDIUM
  申请人：ISP INVESTMENTS LLC

  公开号：US20200407470A1

  公开（公告）日：2020-12-31

  The invention provides a method for preparation of homopolymers and non-homopolymers comprising polymerizing in an aqueous medium a monomer comprising at least one acryloyl moiety and at least one functionalized or unfunctionalized lactam moiety, and optionally at least one hydrophilic or hydrophobic comonomer, in the presence of at least one chain transfer agent and at least one non-radiation initiator. Exemplerary diblock polymers prepared by the method have the structure: where subscripts x, y, and z and variables R, R 8 , R 9 and R 10 are described herein.
• [EN] BLOCK COPOLYMER SYNTHESIS<br/>[FR] SYNTHESE DE COPOLYMERES A BLOCS
  申请人：UNIV SHEFFIELD

  公开号：WO2013017825A1

  公开（公告）日：2013-02-07

  The present invention relates to a method of preparing, in an alcohol-based medium, colloidally stable polymeric particles comprising an alcohol-insoluble block copolymer of Formula B : Formula B wherein P1 represents an alcohol-soluble polymeric component derived from a suitable monomer M1 and P2 represents a substantially alcohol-insoluble polymeric component derived from an alcohol-soluble monomer M2. The block copolymer of Formula B is formed by a radical addition fragmentation chain transfer (RAFT) polymerisation of the alcohol-soluble M2 monomers in the presence of an alcohol-soluble macromolecular chain transfer agent (macro- CTA) of the formula P1-X, where X is a suitable RAFT chain transfer agent. The resulting diblock copolymer particles are formed in situ during the course of the RAFT polymerisation reaction. As such, particles of varying size, morphology and surface charge can be duly prepared with very high monomer conversions for M2 by varying the reaction conditions.
• [EN] METHOD OF PREPARING MONOMERS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE MONOMÈRES
  申请人：UNIV SHEFFIELD

  公开号：WO2014037715A1

  公开（公告）日：2014-03-13

  The present invention relates to a method of preparing certain monomers for use in reversible addition fragmentation chain transfer (RAFT) polymerisations, particularly glycerol methacrylate monomers. The invention forms glyceryl esters of (meth)acrylate-based monomers via aqueous hydrolysis of corresponding glycidyl esters via epoxide ring opening at a pH of 4 or greater. The glyceryl ester products may be provided as an aqueous solution which can be used directly in further reactions, especially RAFT polymerisations.