6-hydroxy-1-(4-hydroxyphenylcarbamoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine | 585575-49-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6-hydroxy-1-(4-hydroxyphenylcarbamoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine
• 英文别名: 6-hydroxy-N-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1-benzazepine-1-carboxamide
• CAS: 585575-49-1
• 化学式: C₁₇H₁₈N₂O₃
• 分子量: 298.342
• InChiKey: VSCNWYNPVUUTME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  72.8
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• N-CARBAMOYL NITROGEN-CONTAINING FUSED RING COMPOUNDS AND DRUGS CONTAINING THESE COMPOUNDS AS THE ACTIVE INGREDIENT
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1475368A1

  公开（公告）日：2004-11-10

  The present invention relates to the compound presented by formula (I) (wherein all symbols in formula (I) are the same mean as the description shown in the specification.), mitocondorial benzogeazepin receptor (MBR) antagonist comprising the compound, the preventive and/or treatment medicine against diseases caused by stress of which an active ingredient is the compound. Since the compound represented by formula (I) has MBR antagonistic activity, and controls the production of neurosteroid, it is useful as the preventive and/or treatment medicine against diseases caused by stress.

  本发明涉及由式(I)表示的化合物（式(I)中的所有符号与说明书中的描述相同。 (其中式(I)中的所有符号与说明书中的描述含义相同。)、由该化合物组成的丝裂原苯并氮杂卓受体(MBR)拮抗剂、预防和/或治疗由压力引起的疾病的药物，其有效成分为该化合物。 由于式 (I) 所代表的化合物具有 MBR 拮抗活性，并能控制神经类固醇的产生，因此可用作预防和/或治疗由压力引起的疾病的药物。
• N-carbamoyl nitrogen-containing fused ring compounds and drugs containing these compounds as the active ingredient
  申请人：Seko Takuya

  公开号：US20050101600A1

  公开（公告）日：2005-05-12

  The present invention relates to the compound presented by formula (I) (wherein all symbols in formula (I) are the same mean as the description shown in the specification.), mitocondorial benzogeazepin receptor (MBR) antagonist comprising the compound, the preventive and/or treatment medicine against diseases caused by stress of which an active ingredient is the compound. Since the compound represented by formula (I) has MBR antagonistic activity, and controls the production of neurosteroid, it is useful as the preventive and/or treatment medicine against diseases caused by stress.

  本发明涉及由式(I)表示的化合物（式(I)中的所有符号与说明书中的描述相同。 (其中式(I)中的所有符号与说明书中的描述含义相同。)、由该化合物组成的丝裂原苯并氮杂卓受体(MBR)拮抗剂、预防和/或治疗由压力引起的疾病的药物，其有效成分为该化合物。由于式 (I) 所代表的化合物具有 MBR 拮抗活性，并能控制神经类固醇的产生，因此可用作预防和/或治疗由压力引起的疾病的药物。
• US7368444B2
  申请人：——

  公开号：US7368444B2

  公开（公告）日：2008-05-06