4-fluoro-5-methoxy-3-(2-pyrrolidin-1-ylethyl)-1H-indole | 344790-93-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-fluoro-5-methoxy-3-(2-pyrrolidin-1-ylethyl)-1H-indole
• 英文别名: 4-Fluoro-5-methoxy-3-(2-pyrrolidin-1-yl-ethyl)-1H-indole
• CAS: 344790-93-8
• 化学式: C₁₅H₁₉FN₂O
• 分子量: 262.327
• InChiKey: FJCRAYWNOXUYOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  28.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-溴-4-氟-1H-吲哚 在 copper(l) iodide 、 lithium aluminium tetrahydride 作用下， 以 1,4-二氧六环 、 乙醚 、 乙酸乙酯 为溶剂， 反应 53.5h， 生成 4-fluoro-5-methoxy-3-(2-pyrrolidin-1-ylethyl)-1H-indole
  参考文献：
  名称：

  一种新型的氟化色胺，具有高效的5-羟色胺5-HT1A受体激动剂特性。

  摘要：

  描述了新型氟化色胺的类似物的合成和生物学评估。发现该新化合物1-（4-氟-5-甲氧基吲哚-3-基）吡咯烷（2）是有效的5-羟色胺5-HT1A激动剂。

  DOI：

  10.1016/s0960-894x(01)00062-2

文献信息

• COMPOSITIONS COMPRISING A PSILOCYBIN DERIVATIVE AND A CANNABINOID
  申请人：CaaMTech, LLC

  公开号：US20190142851A1

  公开（公告）日：2019-05-16

  This disclosure pertains to new compositions and methods comprising a psilocybin derivative. In one embodiment, the compositions disclosed herein are used for a method of regulating a neurotransmitter receptor, e.g., a serotonin receptor. In one embodiment, the compositions disclosed herein comprise purified compounds, e.g., a purified psilocybin derivative, a purified cannabinoid, or purified terpene.
• COMPOSITIONS COMPRISING A SEROTONERGIC TRYPTAMINE COMPOUND
  申请人：CAAMTECH, INC.

  公开号：US20210346346A1

  公开（公告）日：2021-11-11

  Disclosed herein are compositions comprising a serotonergic tryptamine compound, combinations thereof, and methods of using them for treating and preventing a variety of human conditions. In one embodiment, disclosed herein are new compositions and methods which comprise a therapeutically effective amount of a first purified psilocybin derivative and a therapeutically effective amount of a second compound. The second compound is selected from the group consisting of a second purified psilocybin derivative, a purified terpene, a serotonergic drug, an adrenergic drug, a dopaminergic drug, a purified erinacine, and a purified hericenone.
• [EN] COMPOSITIONS AND METHODS FOR TREATING MIGRAINE<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE LA MIGRAINE
  申请人：[en]WESANA HEALTH INC.

  公开号：WO2022115798A2

  公开（公告）日：2022-06-02

  As described below, the present disclosure features compositions containing a cannabidiol (CBD) and/or psilocybin, optionally in combination with a mushroom blend. The present disclosure also features methods for treating or preventing migraine, or symptoms thereof, with a cannabidiol and/or psilocybin, optionally in combination with a mushroom blend. The present disclosure also features compositions and methods of using psilocybin in combination with a neurotransmitter activity modulator for the treatment of neurological conditions (e.g., migraine), or symptoms thereof (e.g., anxiety or depression).
• A novel fluorinated tryptamine with highly potent serotonin 5-HT1A receptor agonist properties
  作者：Uroš Laban、Deborah Kurrasch-Orbaugh、Danuta Marona-Lewicka、David E. Nichols

  DOI：10.1016/s0960-894x(01)00062-2

  日期：2001.3

  Synthesis and biological evaluation of a novel fluorinated tryptamine analogue are described. This new compound 1-(4-fluoro-5-methoxyindol-3-yl)pyrrolidine (2) was found to be a potent serotonin 5-HT1A agonist.

  描述了新型氟化色胺的类似物的合成和生物学评估。发现该新化合物1-（4-氟-5-甲氧基吲哚-3-基）吡咯烷（2）是有效的5-羟色胺5-HT1A激动剂。