Bis-(5-methoxycarbonyl-valeryl)-peroxid | 42367-80-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Bis-(5-methoxycarbonyl-valeryl)-peroxid
• CAS: 42367-80-6
• 化学式: C₁₄H₂₂O₈
• 分子量: 318.324
• InChiKey: AJYCUAZCMJUXOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.45
• 重原子数：
  22.0
• 可旋转键数：
  10.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  105.2
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  Bis-(5-methoxycarbonyl-valeryl)-peroxid 以 环己烷 为溶剂， 生成 Adipinsaeure-methyl-<δ-methoxycarbonyl-butyl>-ester
  参考文献：
  名称：

  Goldschmidt,S.; Beer,L., Justus Liebigs Annalen der Chemie, 1961, vol. 641, p. 40 - 50

  摘要：

  DOI：
• 作为产物：
  描述：

  甲基脂肪酰氯 在 吡啶 、 双氧水 作用下， 生成 Bis-(5-methoxycarbonyl-valeryl)-peroxid
  参考文献：
  名称：

  Goldschmidt,S.; Beer,L., Justus Liebigs Annalen der Chemie, 1961, vol. 641, p. 40 - 50

  摘要：

  DOI：

文献信息

• Iron‐Catalyzed Radical Decarboxylative Oxyalkylation of Terminal Alkynes with Alkyl Peroxides
  作者：Xiaotao Zhu、Changqing Ye、Yajun Li、Hongli Bao

  DOI：10.1002/chem.201701830

  日期：2017.8

  An iron‐catalyzed oxyalkylation of alkynes with alkyl peroxides as the alkylating reagents has been investigated. Alkyl peroxides are readily available from aliphatic acids and serve simultaneously as the alkylating reagents and internal oxidants. Primary, secondary, and tertiary alkyl groups of aliphatic acids were readily incorporated into C−C triple bonds and diverse α‐alkylated ketones were synthesized

  已经研究了以烷基过氧化物作为烷基化试剂的炔烃的铁催化的烷氧基化反应。烷基过氧化物可容易地从脂族酸获得，并且同时用作烷基化试剂和内部氧化剂。脂肪酸的伯，仲和叔烷基易于掺入C-C三键中，并合成了多种α-烷基化的酮。机理研究表明，该反应涉及高反应性烷基自由基。观察到铁（III）催化剂催化的月桂酸和水之间的独特平衡。
• Merging Visible-Light Photocatalysis and Transition-Metal Catalysis in Three-Component Alkyl-Fluorination of Olefins with a Fluoride Ion
  作者：Weili Deng、Weiwei Feng、Yajun Li、Hongli Bao

  DOI：10.1021/acs.orglett.8b01658

  日期：2018.7.20

  The light-induced, Ru-catalyzed three-component alkyl-fluorination of olefins under mild reaction conditions is reported. This carbofluorination reaction features a wide substrate scope and good functional group tolerance. A key advantage of this photoredox reaction is the use of nucleophilic fluoride and generic alkyl groups. Late-stage functionalizations are achieved, and a copper-assisted oxidative

  报道了在温和的反应条件下光诱导的，Ru催化的烯烃三组分烷基氟化反应。该碳氟化反应的特点是底物范围广，官能团耐受性好。该光氧化还原反应的关键优势是亲核氟化物和通用烷基的使用。实现了后期功能化，并在机理研究的基础上提出了铜辅助的氧化猝灭机理。
• Cu-Catalyzed Alkylarylation of Vinylarenes with Masked Alkyl Electrophiles
  作者：Xiaotao Zhu、Muqiao Su、Qi Zhang、Yajun Li、Hongli Bao

  DOI：10.1021/acs.orglett.9b04392

  日期：2020.1.17

  A Cu-catalyzed synthesis of a range of value-added 1,1-diarylalkanes by radical alkylarylation of vinylarenes with alkyl peroxides as masked alkyl electrophiles is reported. The reaction features broad substrate scope, good functional group tolerance, and mild reaction conditions. Various bioactive molecules and key pharmaceutical intermediates have been easily synthesized by this method, demonstrating its synthetic value.