N-isopropyl-stearoyl amide | 106438-51-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-isopropyl-stearoyl amide
• 英文别名: N-isopropylstearamide；N-lsopropyl-stearoyl amide；Octadecanamide, N-(1-methylethyl)-；N-propan-2-yloctadecanamide
• CAS: 106438-51-1
• 化学式: C₂₁H₄₃NO
• 分子量: 325.579
• InChiKey: KKKHFKPIVTXUML-UHFFFAOYSA-N

物化性质

• 沸点：
  378.3±10.0 °C(Predicted)
• 密度：
  0.853±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  23
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  异丙胺 、 十八烷酰氯 以 二氯甲烷 为溶剂， 反应 1.5h， 以0.85%的产率得到N-isopropyl-stearoyl amide
  参考文献：
  名称：

  USE OF ENDOCANNABINOID-LIKE COMPOUNDS FOR TREATING CNS DEGENERATIVE DISORDERS

  摘要：

  公开号：

  EP1592418B1

文献信息

• Novel n-acyl-isopropylglycine derivatives
  申请人：Monsanto Company

  公开号：EP0188185A1

  公开（公告）日：1986-07-23

  N-acyt-N-isopropylglycines having the formula wherein R is C1-C20 alkyl, C1-C20 cycloalkyl, aryl, benzyl, or substituted benzyl are useful in the synthesis of N-phosphonomethylglycine.

  式中 R 为 C1-C20 烷基、C1-C20 环烷基、芳基、苄基或取代苄基的 N-乙酰基-N-异丙基甘氨酸可用于合成 N-膦酰甲基甘氨酸。
• New endocannabinoid-like compounds and their use
  申请人：RESEARCH & INNOVATION SOC. COOP. A R.L.

  公开号：EP1900365A2

  公开（公告）日：2008-03-19

  The present invention describes compounds deriving from chemical reactions between saturated or monounsaturated acyl derivatives and primary amines or primary alcohols that display specific cannabinoid-like pharmacological activity without exhibiting the central unwanted side effects typical of synthetic cannabinoids or endocannabinoids acting on central cannabinoid (CB1) receptors. These compounds, having this pharmacological activity, may be utilised to prevent or to treat pathological conditions and diseases in mammals, including human subjects, that may undergo a clinical improvement upon their administration.

  本发明描述了由饱和或单不饱和酰基衍生物与伯胺或伯醇之间的化学反应所产生 的化合物，这些化合物显示出类似大麻素的特殊药理活性，而不会表现出合成大麻 素或作用于中枢大麻素（CB1）受体的内源性大麻素所特有的中枢性不良副作用。这些具有这种药理活性的化合物可用于预防或治疗哺乳动物（包括人类）的病理状况和疾病，服用后可改善临床症状。
• Antiperspirant spray devices and compositions
  申请人：The Procter & Gamble Company

  公开号：US10766646B2

  公开（公告）日：2020-09-08

  A method of filling a hand held spray device is disclosed. The spray device includes a body having a reservoir. The method includes filling the reservoir with a first composition having a non-volatile silicone fluid, an antiperspirant active, an organoclay material, and at least one liquid activation enhancer having a Hansen Solubility Parameter for Hydrogen Bonding, δh between about 2 and about 6 and a light transmittance value greater than 90%. The method further includes filling the reservoir with a liquid fragrance material after the reservoir is filled with the first composition to form an antiperspirant composition, attaching a valve to the body; and filling the reservoir with a propellant, wherein the hand held spray device has a propellant concentration after filling from about 30% to about 90% by weight of the total fill of materials within the reservoir and the non-volatile silicone fluid has a concentration from about 30% to about 70% by weight of the antiperspirant composition.

  本发明公开了一种手持式喷雾装置的加注方法。喷雾装置包括一个具有储液器的主体。该方法包括用第一种组合物填充储液器，该第一种组合物具有非挥发性硅油、止汗活性物质、有机粘土材料和至少一种液体活化增强剂，其氢键的汉森溶解度参数δh 在约 2 和约 6 之间，透光率值大于 90%。该方法还包括在贮存器装满第一种组合物形成止汗剂组合物后，用液体香味材料填充贮存器，将阀门安装到主体上；以及用推进剂填充贮存器，其中手持喷雾装置在填充后的推进剂浓度为贮存器内材料总填充量的约 30% 至约 90%（按重量计），而非挥发性硅酮流体的浓度为止汗剂组合物的约 30% 至约 70%（按重量计）。
• USE IN THERAPY OF ENDOCANNABINOID-LIKE COMPOUNDS
  申请人：Research & Innovation Soc. Coop. A R.L.

  公开号：EP1592418A2

  公开（公告）日：2005-11-09
• Endocannabinoid-like compounds and their use for treating dermatitis
  申请人：Research & Innovation S.p.A.

  公开号：EP1900365B1

  公开（公告）日：2011-03-30