7-methoxy-1H-indole-3-carboxylic acid, 8-methyl-8-azabicyclo(3.2. 1)oct-3-yl ester | 346576-42-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 7-methoxy-1H-indole-3-carboxylic acid, 8-methyl-8-azabicyclo(3.2. 1)oct-3-yl ester
• 英文别名: (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 7-methoxy-1H-indole-3-carboxylate
• CAS: 346576-42-9
• 化学式: C₁₈H₂₂N₂O₃
• 分子量: 314.384
• InChiKey: GMKZFWHCKJSRHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Modified ligand-gated ion channels and methods of use
  申请人：Howard Hughes Medical Institute

  公开号：US10981962B2

  公开（公告）日：2021-04-20

  This document relates to materials and methods for controlling ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.

  本文涉及控制配体门控离子通道（LGIC）活性的材料和方法。例如，提供了包括至少一个具有修饰配体结合结构域（LBD）和/或修饰离子孔结构域（IPD）的 LGIC 亚基的修饰 LGIC。此外，还提供了可与经修饰的 LGIC 结合并激活该 LGIC 的外源 LGIC 配体，以及调节哺乳动物细胞膜上离子转运的方法、调节哺乳动物细胞兴奋性的方法和治疗患有通道病的哺乳动物的方法。
• MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE
  申请人：Howard Hughes Medical Institute

  公开号：US20190169264A1

  公开（公告）日：2019-06-06

  This document relates to materials and methods for modulating ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one LGIC subunit having a modified ligand binding domain (LBD) and/or a modified ion pore domain (IPD) are provided. Also provided are exogenous LGIC ligands that can bind to and activate the modified LGIC, as well as methods of modulating ion transport across the membrane of a cell of a mammal, methods of modulating the excitability of a cell in a mammal, and methods of treating a mammal having a channelopathy.