1-(2-indol-2-yl-phenyl)-3-phenyl-urea | 40754-09-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(2-indol-2-yl-phenyl)-3-phenyl-urea
• 英文别名: 1-(2-(1H-indol-2-yl)phenyl)-3-phenylurea；3-[2-(1H-Indol-2-YL)phenyl]-1-phenylurea；1-[2-(1H-indol-2-yl)phenyl]-3-phenylurea
• CAS: 40754-09-4
• 化学式: C₂₁H₁₇N₃O
• mdl: MFCD15127282
• 分子量: 327.385
• InChiKey: JGKANURYPCIMQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56.9
• 氢给体数：
  3
• 氢受体数：
  1

文献信息

• C-linked cyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
  申请人：Sutton C. James

  公开号：US20060293336A1

  公开（公告）日：2006-12-28

  The present invention provides novel C-linked cyclic compounds and analogues of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, D and W are as defined herein. These compounds are selective inhibitors of the human P2Y 1 receptor which can be used as medicaments.

  本发明提供了新型的C-连接环化合物和Formula (I)的类似物：或其立体异构体、互变异构体、药学上可接受的盐或溶剂形式，其中变量A、B、D和W如本文所定义。这些化合物是人类P2Y1受体的选择性抑制剂，可用作药物。
• C-LINKED CYCLIC ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS
  申请人：Bristol-Myers Squibb Company

  公开号：EP1899299A2

  公开（公告）日：2008-03-19
• LIPOPHILIC PERSONAL CARE COMPOSITION
  申请人：The Procter and Gamble Company

  公开号：EP1901812A1

  公开（公告）日：2008-03-26
• Lipophilic personal care composition
  申请人：Masuda Hisatoshi

  公开号：US20070009457A1

  公开（公告）日：2007-01-11

  Disclosed is a lipophilic personal care composition comprising by weight: (a) from about 5% to about 50% of a polyglycerin fatty acid ester having a polyglycerin of 2-15 units and at least 5 fatty acid residues attached thereto, wherein the fatty acid residue has 18 to 24 carbons; (b) from about 5% to about 50% of an N-long chain acyl acidic amino acid ester of sterol having formula (I): XOC(O)—(CH2) n -CH(NHCOR)—C(O)OY  (I) wherein one of X and Y is an ester residue of sterol selected from the group consisting of phytosterol, cholesterol, lanosterol, stigmasterol, its hydrogenates, and its derivatives, and the other is selected from H, an alkyl or alkenyl of 8-30 carbons, and ester residue of monohydric solid alcohol of 12-38 carbons; COR is a long chain acyl group of 8-22 carbons; and n is an integer of 1 or 2; and having a water holding capability of at least 400%, and is liquid at 25° C.; and (c) from about 5% to about 50% of a dimer acid ester.
• US7700620B2
  申请人：——

  公开号：US7700620B2

  公开（公告）日：2010-04-20