2-ethoxy-valeric acid ethyl ester | 209803-42-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-ethoxy-valeric acid ethyl ester
• 英文别名: α-Aethoxy-n-valeriansaeureaethylester；2-Aethoxy-valeriansaeure-aethylester；Ethyl 2-ethoxypentanoate
• CAS: 209803-42-9
• 化学式: C₉H₁₈O₃
• 分子量: 174.24
• InChiKey: FVMNKDZUGDXPDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-ethoxy-valeric acid ethyl ester 在 氢氧化钾 作用下， 生成 2-乙氧基戊酸
  参考文献：
  名称：

  Blaise; Picard, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1911, vol. 152, p. 960

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 、 sodium ethanolate 作用下， 生成 2-ethoxy-valeric acid ethyl ester
  参考文献：
  名称：

  Blaise; Picard, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1911, vol. 152, p. 960

  摘要：

  DOI：

文献信息

• EP1309721A2
  申请人：——

  公开号：EP1309721A2

  公开（公告）日：2003-05-14
• SYSTEME MONO COMPOSANT A BASE DE LATEX COREACTIFS, PROCEDE DE PREPARATION ET APPLICATION DANS LE DOMAINE DES REVETEMENTS EXEMPTS DE FORMOL
  申请人：Arkema France

  公开号：EP1778804A1

  公开（公告）日：2007-05-02
• 3-(3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINE AND THERAPEUTIC USES THEREOF
  申请人：Samumed, LLC

  公开号：US20170260209A1

  公开（公告）日：2017-09-14

  Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
• [EN] METHODS FOR MODULATING MULTIPLE LINEAGE KINASE PROTEINS AND SCREENING COMPOUNDS WHICH MODULATE MULTIPLE LINEASE KINASE PROTEINS<br/>[FR] PROCEDES PERMETTANT DE MODULER DES PROTEINES KINASE A LIGNEE MULTIPLE ET DE CRIBLER DES COMPOSES LES MODULANT
  申请人：CEPHALON INC

  公开号：WO2002014536A2

  公开（公告）日：2002-02-21

  Methods for identifying compounds which modulate activity of a multiple linease kinase protein and promotes cell survival or cell death comprising the steps of contacting the cell containing the multiple linease protein with the compound, determining whether the compound decreases activity of the multiple linease protein, and determining whether the compound promotes cell survival are provided. Methods for identifying compounds which may be useful in the treatment of neurodegenerative disorders and/or inflammation are also provided. Methods for modulating the activity of a multiple linage kinase protein comprising contacting the protein or a cell containing the protein with an indeno- or indolo-compound of the invention are also provided. Methods of treating nuerodegenerative disorders and/or inflammation are also provided
• [EN] ODULATING MULTIPLE LINEAGE KINASE PROTEINS<br/>[FR] PROCEDES PERMETTANT DE MODULER DES PROTEINES KINASE A LIGNEE MULTIPLE ET DE CRIBLER DES COMPOSES LES MODULANT
  申请人：——

  公开号：WO2002014536A9

  公开（公告）日：2003-12-18

  [EN] Methods for identifying compounds which modulate activity of a multiple linease kinase protein and promotes cell survival or cell death comprising the steps of contacting the cell containing the multiple linease protein with the compound, determining whether the compound decreases activity of the multiple linease protein, and determining whether the compound promotes cell survival are provided. Methods for identifying compounds which may be useful in the treatment of neurodegenerative disorders and/or inflammation are also provided. Methods for modulating the activity of a multiple linage kinase protein comprising contacting the protein or a cell containing the protein with an indeno- or indolo-compound of the invention are also provided. Methods of treating nuerodegenerative disorders and/or inflammation are also provided
  [FR] Cette invention a trait à des procédés permettant d'identifier des composés qui modulent l'activité d'une protéine kinase à lignée multiple et favorisent la survie ou la mort de cellules. Ces procédés consistent à mettre en contact la cellule contenant cette protéine avec le composé, à déterminer si ce composé diminue l'activité de celle-ci et s'il favorise la survie des cellules. L'invention concerne également des procédés permettant d'identifier des composés susceptibles d'être utilisés dans le traitement de troubles neurodégénératifs et/ou inflammatoires. Elle porte, en outre, sur des procédés visant à moduler l'activité de cette protéine, lesquels procédés consistent à mettre en contact la protéine ou la cellule contenant la protéine avec un composé indéno ou indolo. Elle concerne également des méthodes de traitement de troubles neurodégénératifs et/ou inflammatoires.