Oxadibuttersaeure-dimethylester | 5373-91-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Oxadibuttersaeure-dimethylester
• 英文别名: γ,γ'-Oxa-bis；5-oxa-nonanedioic acid dimethyl ester；5-Oxa-nonandisaeure-dimethylester；Bis-(3-carbomethoxy-propyl)-aether；Methyl 4-(4-methoxy-4-oxobutoxy)butanoate
• CAS: 5373-91-1
• 化学式: C₁₀H₁₈O₅
• 分子量: 218.25
• InChiKey: CXQDPEWAQYKXEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Oxadibuttersaeure-dimethylester 、 正丁醇 、 alkaline earth salt of/the/ methylsulfuric acid 生成 4,4'-氧基双(丁-1-醇)
  参考文献：
  名称：

  Rethinking the Analysis of Ethnic Residential Patterns: Segregation, Isolation, or Concentration Thresholds in Auckland, New Zealand?

  摘要：

  Data from the 1996 New Zealand Census on ethnicity in Auckland Urban Area are used to illustrate a new approach to measuring spatial separation. The traditionally employed single‐number indices are found wanting and a method based on thresholds is introduced. This provides more detailed information on the geography of ethnic groups that is consistent with the requirements for testing hypotheses regarding the relationship between social and spatial distance. The results show that (with a few exceptions) Polynesian groups were more encapsulated groups in Auckland than were Asian and European groups, and that most of the European groups—along with the “host society,” the New Zealand Europeans—were not spatially exposed to members of the Polynesian and Asian groups.

  DOI：

  10.1111/j.1538-4632.2002.tb01087.x
• 作为产物：
  描述：

  2,2'-(3-oxa-pentanediyl)-di-malonic acid 在 哌啶 、 硫酸 作用下， 生成 Oxadibuttersaeure-dimethylester
  参考文献：
  名称：

  Rethinking the Analysis of Ethnic Residential Patterns: Segregation, Isolation, or Concentration Thresholds in Auckland, New Zealand?

  摘要：

  Data from the 1996 New Zealand Census on ethnicity in Auckland Urban Area are used to illustrate a new approach to measuring spatial separation. The traditionally employed single‐number indices are found wanting and a method based on thresholds is introduced. This provides more detailed information on the geography of ethnic groups that is consistent with the requirements for testing hypotheses regarding the relationship between social and spatial distance. The results show that (with a few exceptions) Polynesian groups were more encapsulated groups in Auckland than were Asian and European groups, and that most of the European groups—along with the “host society,” the New Zealand Europeans—were not spatially exposed to members of the Polynesian and Asian groups.

  DOI：

  10.1111/j.1538-4632.2002.tb01087.x

文献信息

• Crystal forms of cytostatics
  申请人：Novartis AG

  公开号：EP1428826A2

  公开（公告）日：2004-06-16

  The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.

  本发明涉及一种在培养基中浓缩埃坡霉素的新工艺、一种生产埃坡霉素的新工艺、一种分离埃坡霉素 A 和 B 的新工艺和一种通过诱变获得的生产埃坡霉素的新菌株，以及与之相关的各个方面。此外，还介绍了埃博霉素 B 的新晶体形态。
• Fermentative preparation process for and crystal forms of cytostatics
  申请人：——

  公开号：US20020165256A1

  公开（公告）日：2002-11-07

  The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.

  本发明涉及一种在培养基中浓缩埃坡霉素的新工艺、一种生产埃坡霉素的新工艺、一种分离埃坡霉素 A 和 B 的新工艺和一种通过诱变获得的生产埃坡霉素的新菌株，以及与之相关的各个方面。此外，还介绍了埃博霉素 B 的新晶体形态。
• Genes for the biosynthesis of epothilones
  申请人：——

  公开号：US20020192778A1

  公开（公告）日：2002-12-19

  Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.

  从以下植物中分离出核酸分子 核酸分子 的核酸分子，这些核酸分子编码生物合成埃博霉素所需的多肽。本发明公开了用本发明基因转化的重组宿主生产埃博霉素的方法。通过这种方法，可以生产出足够多的埃博霉素，使其能够纯化并用于药物制剂，如治疗癌症的药物制剂。
• Transannular Interaction between Sulfide and Ketone Groups¹
  作者：Nelson J. Leonard、Terry W. Milligan、Theodore L. Brown

  DOI：10.1021/ja01500a063

  日期：1960.8
• FERMENTATIVE PREPARATION PROCESS FOR CYTOSTATICS AND CRYSTAL FORMS THEREOF
  申请人：Novartis AG

  公开号：EP1054994B1

  公开（公告）日：2004-11-17