5-Ethoxycarbonyl-7-methyl-2-oxindol | 40800-75-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-Ethoxycarbonyl-7-methyl-2-oxindol
• 英文别名: 5-Ethoxycarbonyl-7-methyl-2-oxindole；ethyl 7-methyl-2-oxo-1,3-dihydroindole-5-carboxylate
• CAS: 40800-75-7
• 化学式: C₁₂H₁₃NO₃
• 分子量: 219.24
• InChiKey: SQQUJWGQPUJXFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-Ethoxycarbonyl-7-methyl-3-methylthio-2-oxindole 、 乙醇 在 镍 作用下， 以to give 0.44 g (2.0l mmol, 67% yield) of 5-ethoxycarbonyl-7-methyl-2-oxindole, m.p. 238° -241°的产率得到5-Ethoxycarbonyl-7-methyl-2-oxindol
  参考文献：
  名称：

  Synthesis of oxindoles from anilines and intermediates therein

  摘要：

  通过将N-卤代苯胺与β-硫酯或β-硫酰胺反应形成氮杂硫鎓卤化物来制备氧化吲哚和其中间体，将氮杂硫鎓卤化物与碱反应形成ortho-[硫醚（烃氧羰基）烷基]苯胺或[硫醚（氨基羰基）烷基]苯胺，将ortho-取代苯胺与酸反应形成3-硫醚-2-氧化吲哚，然后使用Raney镍还原3-硫醚-2-氧化吲哚以形成2-氧化吲哚。

  公开号：

  US03996264A1

文献信息

• Synthesis of oxindoles from anilines and .beta.-thio carboxylic esters
  申请人：The Ohio State University Research Foundation

  公开号：US03972894A1

  公开（公告）日：1976-08-03

  Preparing oxindoles and intermediates therefor by reacting an N-haloaniline with .beta.-thio esters or .beta.-thio amides to form an azasulfonium halide, reacting the azasulfonium halide with a base to form an ortho-[thio-ether (hydrocarbonoxycarbonyl) alkyl]aniline, or a [thio-ether (aminocarbonyl) alkyl]aniline, reacting the orthosubstituted aniline with an acid to form a 3-thio-ether-2-oxindole, and then reducing the 3-thio-ether-2-oxindole with Raney Nickel to form the 2-oxindole.

  通过将N-卤代苯胺与β-硫酯或β-硫酰胺反应形成氮杂环硫鎓卤化物，然后将氮杂环硫鎓卤化物与碱反应形成ortho-[硫醚（碳氢氧羰基）烷基]苯胺或[硫醚（氨基氧羰基）烷基]苯胺，然后将ortho取代苯胺与酸反应形成3-硫醚-2-吲哚酮，最后使用Raney镍还原3-硫醚-2-吲哚酮以形成2-吲哚酮。
• Ortho-[(alkylthio)(aminocarbonyl)methyl]anilines
  申请人：The Ohio State University Research Foundation

  公开号：US04056569A1

  公开（公告）日：1977-11-01

  Preparing oxindoles and intermediates therefor by reacting an N-haloaniline with .beta.-thio esters or .beta.-thio amides to form an azasulfonium halide, reacting the azasulfonium halide with a base to form an ortho-[thioether (hydrocarbonoxycarbonyl) alkyl]aniline, or a [thioether (aminocarbonyl) alkyl]aniline, reacting the orthosubstituted aniline with an acid to form a 3-thio-ether-2-oxindole, and then reducing the 3-thio-ether-2-oxindole with Raney Nickel to form the 2-oxindole.

  通过将N-卤代苯胺与.beta.-硫酯或.beta.-硫酰胺反应形成氮杂硫鎓卤化物，然后将氮杂硫鎓卤化物与碱反应形成ortho-[硫醚（烃氧羰基）烷基]苯胺或[硫醚（氨基羰基）烷基]苯胺，再将其与酸反应形成3-硫醚-2-噁唑酮，最后使用Raney镍还原3-硫醚-2-噁唑酮以形成2-噁唑酮。
• Interspecific tree named ‘Sherri's Flavor’
  申请人：Zaiger Gary Neil

  公开号：USPP029882P2

  公开（公告）日：2018-11-27

  A new and distinct variety of interspecific tree. The following features of the tree and its fruit are characterized with the tree budded on ‘Nemaguard’ Rootstock (non-patented), grown on Handford sandy loam soil with Storie Index rating 95, in USDA Hardiness Zone 9, near Modesto, Calif., with standard commercial fruit growing practices, such as pruning, thinning, spraying, irrigation and fertilization. Its novelty consist of the following combination of desirable features: 1. Tree having a vigorous, upright growth habit. 2. Tree being a regular and productive bearer of large size, yellow flesh fruit. 3. Fruit with an attractive, dark purple skin color. 4. Fruit with very good flavor and eating quality. 5. Fruit with good storage and shipping quality.

  一种新的独特的种间树的品种。该树及其果实的以下特征是在“Nemaguard”砧木（未受专利保护）上嫁接的树上表征的，生长在加利福尼亚州莫德斯托附近的USDA硬度区9的Handford沙质壤土上，具有Storie指数评级95，采用标准的商业水果种植实践，如修剪、稀疏、喷雾、灌溉和施肥。其新颖性在于以下理想特征的组合：1.树具有旺盛的直立生长习性。2.树是一个规律性和高产的大型、黄色果肉的果树。3.果实具有迷人的深紫色皮肤。4.果实具有非常好的口感和食用品质。5.果实具有良好的贮藏和运输品质。
• US3972894A
  申请人：——

  公开号：US3972894A

  公开（公告）日：1976-08-03
• US3996264A
  申请人：——

  公开号：US3996264A

  公开（公告）日：1976-12-07