4-溴-2-(5-溴-2-羟基苯基)磺酰基苯酚 | 5336-23-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-溴-2-(5-溴-2-羟基苯基)磺酰基苯酚
• 英文名称: 4,4'-dibromo-2,2'-sulfonyl-di-phenol
• 英文别名: Bis-(5-brom-2-hydroxy-phenyl)-sulfon；4,4'-Dibrom-2,2'-sulfonyl-di-phenol；2,2'-Sulfonylbis(4-bromophenol)；4-bromo-2-(5-bromo-2-hydroxyphenyl)sulfonylphenol
• CAS: 5336-23-2
• 化学式: C₁₂H₈Br₂O₄S
• 分子量: 408.067
• InChiKey: NZPRBTZJWXINLY-UHFFFAOYSA-N

物化性质

• 熔点：
  206-207 °C (decomp)
• 沸点：
  549.2±50.0 °C(Predicted)
• 密度：
  1.971±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2908999090

反应信息

• 作为反应物：
  描述：

  4-溴-2-(5-溴-2-羟基苯基)磺酰基苯酚 生成 bis-(2-acetoxy-5-bromo-phenyl)-sulfone
  参考文献：
  名称：

  2-Hydroxyphenyl Sulfoxides and 2-Hydroxyphenyl Sulfones

  摘要：

  DOI：

  10.1021/ja01218a029
• 作为产物：
  描述：

  5,5'-dibromo-2,2'-dihydroxydiphenyl sulfide 在 双氧水 、 溶剂黄146 作用下， 生成 4-溴-2-(5-溴-2-羟基苯基)磺酰基苯酚
  参考文献：
  名称：

  2-Hydroxyphenyl Sulfoxides and 2-Hydroxyphenyl Sulfones

  摘要：

  DOI：

  10.1021/ja01218a029

文献信息

• GAIN-OF-FUNCTION BCL-2 INHIBITORS
  申请人：HOCKENBERY David

  公开号：US20120252839A1

  公开（公告）日：2012-10-04

  Compounds are described that are useful for treating an apoptosis-associated disease, which are specifically cytotoxic to tumor cells that are overexpressing Bcl-x L , and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-x L . Also described is a method for treating an apoptosis-associated disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an active compound that is specifically cytotoxic to tumor cells that are overexpressing Bcl-x L , and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-x L . Several scaffolds of active compounds are described.
• COMPOUNDS AND THERAPEUTIC USES
  申请人：Unity Biotechnology, Inc.

  公开号：US20170281649A1

  公开（公告）日：2017-10-05

  Disclosed herein are compounds that are effective for treatment of various disease states associated with senescence. The disclosed compounds can be used to eliminate senescent cells for disease treatment. The dosing of the compounds includes both single administration and regimens of cycling dosages.
• US8865901B2
  申请人：——

  公开号：US8865901B2

  公开（公告）日：2014-10-21
• [EN] METHOD OF INHIBITING BCL-2-RELATED SURVIVAL PROTEINS<br/>[FR] PROCÉDÉ DESTINÉ À INHIBER DES PROTÉINES DE SURVIE APPARENTÉES AUX BCL-2
  申请人：HUTCHINSON FRED CANCER RES

  公开号：WO2011041731A2

  公开（公告）日：2011-04-07

  A method for treating an apoptosis-associated disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an active compound that is specifically cytotoxic to tumor cells that are overexpressing Bcl-xL, and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-xL. Several scaffolds of active compounds are described.
• 2-Hydroxyphenyl Sulfoxides and 2-Hydroxyphenyl Sulfones
  作者：William S. Gump、James C. Vitucci

  DOI：10.1021/ja01218a029

  日期：1945.2