4-溴-2-(6-溴-3-吡啶基)吡啶 | 51888-09-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 中文名称: 4-溴-2-(6-溴-3-吡啶基)吡啶
• 中文别名: 1-甲基-4-(3-(2-氯-吩噻嗪-10-基)丙基)-哌嗪一氢甲烷磺酸酯；丙氯拉嗪甲磺酸盐；二甲烷磺酸丙氯拉嗪；苯丙酸,b-氨基-,乙基酯,(bS)-；1-甲基-4-(3-(2-氯-吩噻嗪-10-基)丙基)-哌嗪甲烷磺酸氢盐
• 英文名称: prochlorperazine methansulfonate
• 英文别名: 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine monomethanesulphonate；Prochlorperazinmesylat；Prochlorperazin；Prochlorperazine hydrogen methanesulfonate；2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine;methanesulfonic acid
• CAS: 51888-09-6；3111-70-4
• 化学式: CH₄O₃S*C₂₀H₂₄ClN₃S
• 分子量: 470.057
• InChiKey: WLFCZUKGFJNFQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.08
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  97.8
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Compositions for Nasal Administration of Phenothiazines
  申请人：GUY David

  公开号：US20100215730A1

  公开（公告）日：2010-08-26

  Provided herein are pharmaceutical compositions comprising phenothiazines or derivatives thereof that are formulated for nasal administration. Also provided herein are methods of utilizing the same.

  本文提供了一种含有苯并噻唑或其衍生物的药物组合物，该药物组合物适用于鼻腔给药。本文还提供了使用该药物组合物的方法。
• PROCESS FOR PRODUCING HARD CAPSULE
  申请人：Shionogi Qualicaps Co., Ltd.

  公开号：EP1044682A1

  公开（公告）日：2000-10-18

  A method of manufacturing hard capsules is characterized by comprising the steps of dispersing a water-soluble cellulose derivative in hot water and cooling the dispersion to effect dissolution of the water-soluble cellulose derivative in the water, adding and dissolving a gelling agent in the water-soluble cellulose derivative solution to give a capsule-preparing solution, dipping a capsule-forming pin into the capsule-preparing solution at a predetermined temperature, then drawing out the pin and inducing gelation of the capsule-preparing solution adhering to the pin.

  一种制造硬胶囊的方法，其特征在于包括以下步骤：将水溶性纤维素衍生物分散在热水中，然后冷却分散液，使水溶性纤维素衍生物溶解在水中、在水溶性纤维素衍生物溶液中加入并溶解胶凝剂，得到胶囊制备溶液，在预定温度下将胶囊成型针浸入胶囊制备溶液中，然后拔出针，使粘附在针上的胶囊制备溶液凝胶化。
• PHARMACEUTICAL COMPOSITION FOR EXTERNAL APPLICATION CONTAINING PROCHLORPERAZINE
  申请人：Nippon Zoki Pharmaceutical Co., Ltd.

  公开号：EP2298313A1

  公开（公告）日：2011-03-23

  Disclosed is a novel pharmaceutical composition for external application for increasing the permeation of prochlorperazine or a pharmaceutically acceptable salt thereof through the skin to allow prochlorperazine or the pharmaceutically acceptable salt thereof to exhibit its excellent pharmacological activity. Specifically disclosed is a novel pharmaceutical composition for external application which contains prochlorperazine or a pharmaceutically acceptable salt thereof as an active ingredient and further contains menthol. The composition contains, as an active ingredient, prochlorperazine which has been widely used clinically as the first-line drug of a therapeutic agent for nausea or vomiting before or after a surgery or the like, and is extremely highly useful as a transdermally absorbable antiemetic agent that has excellent efficacy and car be used safely over a long period.

  本发明公开了一种新型外用药物组合物，该组合物可增加丙氯苯嗪或其药学上可接受的盐在皮肤中的渗透性，从而使丙氯苯嗪或其药学上可接受的盐发挥其卓越的药理活性。具体公开了一种新型外用药物组合物，它含有作为活性成分的丙氯丙嗪或其药学上可接受的盐，并进一步含有薄荷醇。该组合物含有作为活性成分的丙氯苯嗪，丙氯苯嗪在临床上被广泛用作治疗手术前后恶心或呕吐等症状的一线药物，作为一种可透皮吸收的止吐药，丙氯苯嗪具有极高的效用，而且可以长期安全使用。
• Drug delivery device for delivery of two or more independently user selectable multiple doses of medicaments with user operable variable dose locking mechanisms
  申请人：Wockhardt Limited

  公开号：US10376649B2

  公开（公告）日：2019-08-13

  It may be one of the aspects of the invention that a drug delivery device for delivery of two or more independently user selectable multiple doses of medicaments contained in separate cartridges of the medicament reservoirs within a single device operatively connected to a single dispense interface which may be operatively connected to a single activation button; It may be another aspect of the invention that unlocking of the user operable variable dose locking mechanism of the drug delivery device may be easily carried out by one hand operation by a lock slider unlock by the user.

  本发明的一个方面可能是，一种给药装置用于给药两个或多个独立的用户可选择的多剂量药剂，这些药剂分别装在单个装置内的药剂储藏盒中，该装置可操作地连接到单个给药接口，该接口可操作地连接到单个激活按钮；本发明的另一个方面可能是，用户可通过单手操作锁定滑块解锁给药装置的用户可操作可变剂量锁定机构。
• Pharmaceutical compositions containing phenothiazines
  申请人：RECKITT AND COLMAN PRODUCTS LIMITED

  公开号：EP0180364B1

  公开（公告）日：1990-03-07