tert-butyl (4-aminopentan-2-yl)carbamate | 1564817-06-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl (4-aminopentan-2-yl)carbamate
• 英文别名: tert-butyl N-(4-aminopentan-2-yl)carbamate
• CAS: 1564817-06-6
• 化学式: C₁₀H₂₂N₂O₂
• 分子量: 202.297
• InChiKey: HVQMFOQHGQTVAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl (4-aminopentan-2-yl)carbamate 在 potassium carbonate 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 20.5h， 生成 di-tert-butyl ((butane-1,4-diylbis(azanediyl))bis(pentane-1,3-diyl))dicarbamate
  参考文献：
  名称：

  [EN] MUCOSAL ADMINISTRATION METHODS AND FORMULATIONS
  [FR] MÉTHODES ET FORMULATIONS D'ADMINISTRATION PAR VOIE MUQUEUSE

  摘要：

  The present disclosure provides compositions and methods for the preparation, manufacture, and therapeutic use of lipid nanoparticles comprising nucleic acid vaccines, e.g., mRNA vaccines, for delivery to mucosal surfaces.

  公开号：

  WO2023154818A1

文献信息

• AMATOXIN-ARMED THERAPEUTIC CELL SURFACE BINDING COMPONENTS DESIGNED FOR TUMOUR THERAPY
  申请人：Deutsches Krebsforschungszentrum

  公开号：US20160089450A1

  公开（公告）日：2016-03-31

  The invention relates to tumour therapy. In one aspect, the present invention relates to conjugates of a toxin and a target-binding moiety, e.g. an antibody, which are useful in the treatment of cancer. In particular, the toxin is an amatoxin, and the target-binding moiety is preferably directed against tumour-associated antigens. In particular, the amatoxin is conjugated to the antibody by linker moieties. In particular the linker moieties are covalently bound to functional groups located in positions of the amatoxin proved as preferred positions for the attachment of linkers with respect to optimum antitumor activity. In a further aspect the invention relates to pharmaceutical compositions comprising such target-binding moiety toxin conjugates and to the use of such target-binding moiety toxin conjugates for the preparation of such pharmaceutical compositions. The target-binding moiety toxin conjugates and pharmaceutical compositions of the invention are useful for the treatment of cancer.

  本发明涉及肿瘤治疗。在一个方面，本发明涉及毒素和靶向结合基团（例如抗体）的共轭物，其在癌症治疗中有用。特别是，毒素是一种阿马毒素，而靶向结合基团最好是针对肿瘤相关抗原的。特别是，阿马毒素通过连接基团与抗体结合。特别是，连接基团是共价结合到阿马毒素中的位置的功能基团上的，这些位置被证明是连接剂与最佳抗肿瘤活性相关的首选位置。在另一个方面，本发明涉及包含这种靶向结合基团毒素共轭物的制药组合物，并且涉及使用这种靶向结合基团毒素共轭物制备这种制药组合物。本发明的靶向结合基团毒素共轭物和制药组合物可用于癌症治疗。
• [EN] LIPID AMINES<br/>[FR] AMINES LIPIDIQUES
  申请人：[en]MODERNATX, INC.

  公开号：WO2023076598A1

  公开（公告）日：2023-05-04

  Provided are lipid amine compounds which are useful in the preparation of lipid nanoparticle compositions for delivery of therapeutic or prophylactic payload into cells.