cyclopentyl-(5-methyl-2-[1,3,4]oxadiazole-2-yl-1H-indole-7-yl)-amine | 1120343-11-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: cyclopentyl-(5-methyl-2-[1,3,4]oxadiazole-2-yl-1H-indole-7-yl)-amine
• 英文别名: cyclopentyl-(5-methyl-2-[1,3,4]oxadiazol-2-yl-1H-indol-7-yl)-amine；N-cyclopentyl-5-methyl-2-(1,3,4-oxadiazol-2-yl)-1H-indol-7-amine
• CAS: 1120343-11-4
• 化学式: C₁₆H₁₈N₄O
• 分子量: 282.345
• InChiKey: VIYIVKQQLLSMSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  66.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT
  申请人：Kim Soon Ha

  公开号：US20100291533A1

  公开（公告）日：2010-11-18

  The present invention relates to a composition for preserving cells, tissues and organs, comprising as an active ingredient indole and indazole compounds of formula (1), or a pharmaceutically acceptable salt or isomer thereof, which are effective for preventing injury of organs, isolated cell systems or tissues caused by cold storage, transplant operation or post-transplantation reperfusion; a preservation method; and a preparation method of the composition.

  本发明涉及一种用于保存细胞、组织和器官的组合物，其中包括作为活性成分的式（1）的吲哚和吲唑化合物，或其药用可接受的盐或异构体，对于预防由冷藏、移植手术或移植后再灌注引起的器官、分离的细胞系统或组织的损伤具有有效性；一种保存方法；以及该组合物的制备方法。
• US8349885B2
  申请人：——

  公开号：US8349885B2

  公开（公告）日：2013-01-08
• [EN] INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT<br/>[FR] DÉRIVÉS D'INDOLE ET D'INDOLAZOLE POSSÉDANT UN EFFET DE CONSERVATION DE CELLULES, DE TISSUS ET D'ORGANES
  申请人：——

  公开号：WO2009088192A2

  公开（公告）日：2009-07-16

  본 발명은 기관, 독립된 세포시스템 또는 조직의 저온보관, 이식수술 또는 이식 후 발생하는 재관류에 의한 손상을 예방하는 효과를 지닌 화학식 (1)의 인돌 및 인다졸 화합물, 약제학적으로 허용되는 그의 염 또는 이성체를 유효 성분으로 함유함을 특징으로 하는 세포, 조직 및 장기 보존제 조성물, 보존 방법 및 조성물의 제조방법에 관한 것이다.