N-allyl-3-(allyloxy)aniline | 1182347-13-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-allyl-3-(allyloxy)aniline
• 英文别名: 3-prop-2-enoxy-N-prop-2-enylaniline
• CAS: 1182347-13-2
• 化学式: C₁₂H₁₅NO
• 分子量: 189.257
• InChiKey: VCWUJSXZQNKHLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-溴丙烯 、 3-氨基苯酚 在 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 4.5h， 以17%的产率得到3-(allylamino)phenol
  参考文献：
  名称：

  3-Substituted Anilines as Scaffolds for the Construction of Glutamine Synthetase and DXP-Reductoisomerase Inhibitors

  摘要：

  Access to a series of truncated ATP analogs, as potential anti-tuberculosis agents, has been explored via alkylation and acylation of 3-aminophenol, whereas chloroacetylation, using chloroacetyl chloride, and subsequent Arbuzov phosphonation of a series of 3-substituted anilines have afforded a series of phosphonate derivatives as potential antimalarial agents.

  DOI：

  10.1080/00397910802663444

文献信息

• 3-Substituted Anilines as Scaffolds for the Construction of Glutamine Synthetase and DXP-Reductoisomerase Inhibitors
  作者：Marius Mutorwa、Sheriff Salisu、Gregory L. Blatch、Colin Kenyon、Perry T. Kaye

  DOI：10.1080/00397910802663444

  日期：2009.7.7

  Access to a series of truncated ATP analogs, as potential anti-tuberculosis agents, has been explored via alkylation and acylation of 3-aminophenol, whereas chloroacetylation, using chloroacetyl chloride, and subsequent Arbuzov phosphonation of a series of 3-substituted anilines have afforded a series of phosphonate derivatives as potential antimalarial agents.