rac-5-[(5-bromo-2-fluorophenyl)(hydroxy)methyl]-N,N-dimethyl-3-(trifluoromethyl)-1H-pyrazole-1-sulfonamide | 1369543-50-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: rac-5-[(5-bromo-2-fluorophenyl)(hydroxy)methyl]-N,N-dimethyl-3-(trifluoromethyl)-1H-pyrazole-1-sulfonamide
• 英文别名: 5-[(5-bromo-2-fluorophenyl)-hydroxymethyl]-N,N-dimethyl-3-(trifluoromethyl)pyrazole-1-sulfonamide
• CAS: 1369543-50-9
• 化学式: C₁₃H₁₂BrF₄N₃O₃S
• 分子量: 446.22
• InChiKey: TYGKVGCFXZPHTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  83.8
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• 4,7-DIHYDRO-PYRAZOLO[1,5-a]PYRAZIN-6-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)
  申请人：Trabanco-Suárez Andrés Avelino

  公开号：US20130190318A1

  公开（公告）日：2013-07-25

  The present invention relates to novel 4,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl-amine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid.

  本发明涉及作为β-分泌酶抑制剂的新型4,7-二氢吡唑并[1,5-a]吡嗪-6-基胺衍生物，该酶也被称为β-位点淀粉样蛋白裂解酶、BACE、BACE1、Asp2或memapsin2。该发明还涉及包含这些化合物的药物组合物，制备这些化合物和组合物的方法，以及利用这些化合物和组合物预防和治疗涉及β-分泌酶的疾病，如阿尔茨海默病（AD）、轻度认知障碍、老年痴呆、带有Lewy小体的痴呆、唐氏综合征、与中风相关的痴呆、与帕金森病相关的痴呆或与β-淀粉样蛋白相关的痴呆。
• 4,7-Dihydro-pyrazolo[1,5-a]pyrazin-6-ylamine derivatives useful as inhibitors of beta secretase (BACE)
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2619207B1

  公开（公告）日：2014-11-12
• US8609660B2
  申请人：——

  公开号：US8609660B2

  公开（公告）日：2013-12-17