5-[2-Morpholin-4-yl-9-(1-phenylpiperidin-4-yl)purin-6-yl]pyrazin-2-amine | 1202494-19-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 5-[2-Morpholin-4-yl-9-(1-phenylpiperidin-4-yl)purin-6-yl]pyrazin-2-amine
• CAS: 1202494-19-6
• 化学式: C₂₄H₂₇N₉O
• 分子量: 457.538
• InChiKey: ZPPLZKXWFIBUHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• [EN] PYRAZINE SUBSTITUTED PURINES<br/>[FR] PURINES SUBSTITUÉES PAR LA PYRAZINE
  申请人：S BIO PTE LTD

  公开号：WO2009157880A1

  公开（公告）日：2009-12-30

  The present invention relates to purine compounds of formula (I) that are useful as kinase inhibitors. More particularly, the present invention relates to purine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative conditions or disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative conditions or disorders including tumours and cancers as well as other disorders or conditions related to or associated with PI3K and/or mTOR kinases.

  本发明涉及式（I）的嘌呤化合物，其作为激酶抑制剂具有用途。更具体地，本发明涉及嘌呤化合物、其制备方法、含有这些化合物的制药组合物以及这些化合物在治疗增殖性疾病或紊乱方面的用途。这些化合物可以作为药物用于治疗许多增殖性疾病或紊乱，包括肿瘤和癌症以及与PI3K和/或mTOR激酶相关或相关的其他紊乱或疾病。
• PYRAZINE SUBSTITUTED PURINES
  申请人：Nagaraj Harish Kumar Mysore

  公开号：US20110105500A1

  公开（公告）日：2011-05-05

  The present invention relates to purine compounds of formula (I) that are useful as kinase inhibitors. More particularly, the present invention relates to purine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative conditions or disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative conditions or disorders including tumours and cancers as well as other disorders or conditions related to or associated with PI3K and/or mTOR kinases.

  本发明涉及公式(I)的嘌呤化合物，其作为激酶抑制剂具有用途。更具体地，本发明涉及嘌呤化合物、其制备方法、含有这些化合物的制药组合物以及在治疗增殖性疾病或疾病方面使用这些化合物的用途。这些化合物可用作药物治疗多种增殖性疾病或疾病，包括肿瘤和癌症，以及与PI3K和/或mTOR激酶相关或相关的其他疾病或状况。