1,2-bis(4-bromophenyl)-6,7-dihydro-3-methoxy-6,6-dimethyl-1H-indol-4(5H)-one | 1436868-36-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1,2-bis(4-bromophenyl)-6,7-dihydro-3-methoxy-6,6-dimethyl-1H-indol-4(5H)-one
• 英文别名: 1,2-Bis(4-bromophenyl)-3-methoxy-6,6-dimethyl-5,7-dihydroindol-4-one；1,2-bis(4-bromophenyl)-3-methoxy-6,6-dimethyl-5,7-dihydroindol-4-one
• CAS: 1436868-36-8
• 化学式: C₂₃H₂₁Br₂NO₂
• 分子量: 503.233
• InChiKey: OTZWEYLQFXXWSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  31.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-(4-溴苯胺基)-5,5-二甲基环己-2-烯-1-酮 、 甲醇 、 4-溴苯基水合乙二醛 在 对甲苯磺酸 作用下， 反应 0.37h， 以81%的产率得到1,2-bis(4-bromophenyl)-6,7-dihydro-3-methoxy-6,6-dimethyl-1H-indol-4(5H)-one
  参考文献：
  名称：

  Three-component synthesis of poly-substituted tetrahydroindoles through p-TsOH promoted alkoxylation

  摘要：

  Concise and efficient three-component domino reactions to highly substituted tetrahydroindole derivatives promoted by p-TsOH have been developed under microwave irradiation condition. The direct C3-alkoxylation of indole framework was achieved in a one-pot operation. The reaction proceeds at fast rates and can be finished within 30 mm, which makes workup convenient to give good chemical yields. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.04.029

文献信息

• Three-component synthesis of poly-substituted tetrahydroindoles through p-TsOH promoted alkoxylation
  作者：Qing-Qing Shi、Li-Ping Fu、Yu Shi、Hua-Qin Ding、Jing-Hua Luo、Bo Jiang、Shu-Jiang Tu

  DOI：10.1016/j.tetlet.2013.04.029

  日期：2013.6

  Concise and efficient three-component domino reactions to highly substituted tetrahydroindole derivatives promoted by p-TsOH have been developed under microwave irradiation condition. The direct C3-alkoxylation of indole framework was achieved in a one-pot operation. The reaction proceeds at fast rates and can be finished within 30 mm, which makes workup convenient to give good chemical yields. (C) 2013 Elsevier Ltd. All rights reserved.