7-guanidinoheptanoic acid | 73427-55-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7-guanidinoheptanoic acid
• 英文别名: 7-(diaminomethylideneamino)heptanoic acid
• CAS: 73427-55-1
• 化学式: C₈H₁₇N₃O₂
• 分子量: 187.242
• InChiKey: TURWKAWYHMVRNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  102
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-guanidinoheptanoic acid 以 N-甲基乙酰胺 、 盐酸 为溶剂， 生成 N,N-dicyclohexylurea
  参考文献：
  名称：

  Spergualin-related compounds and process for the preparation thereof

  摘要：

  本发明涉及一种新的与spergualin相关的化合物及其生产方法。这种具有高抗肿瘤活性的新化合物由一般公式##STR1##表示，其中R.sub.1代表氢原子、羟基或具有1至10个碳原子的脂肪酰氧基，R.sub.2代表氨基酸残基（除了α-羟基甘氨酸残基）由α-或ω-氨基和α-羧基中分别去除一个氢原子和羟基得到，该氨基酸残基与相邻的羰基和氨基形成酸酰胺键，m为4至6的整数。

  公开号：

  US04529549A1
• 作为产物：
  描述：

  氨基亚氨基甲烷磺酸 、 7-氨基庚酸 在 potassium carbonate 作用下， 以 水 为溶剂， 生成 7-guanidinoheptanoic acid
  参考文献：
  名称：

  Conformationally flexible platelet aggregation inhibitors based on the tetrapeptide Arg-Gly-Asp-Arg

  摘要：

  A series of nonpeptide fibrinogen receptor antagonists based upon the tetrapeptide Arg-Gly-Asp-Arg were prepared. These relatively simple derivatives incorporate a high degree of conformational flexibility that was anticipated to allow them to attain the requisite conformation for binding to the platelet fibrinogen receptor. Optimization of the distances between the required acidic and basic functional groups led eventually to compound 7, which is a one hundred-fold more potent inhibitor of platelet aggregation than the peptide it is based upon.

  DOI：

  10.1016/s0223-5234(99)80069-5

文献信息

• IMAGE-GUIDED ENERGY DEPOSITION FOR TARGETED DRUG DELIVERY
  申请人：Li King Chuen

  公开号：US20110270151A1

  公开（公告）日：2011-11-03

  Disclosed are compositions and methods for targeted drug delivery using image-guided energy deposition to help localize active compounds to particular sites within the body of an animal. Also provided are compounds and formulations thereof for use in the targeted administration of therapeutically, prophylactically, and/or diagnostically effective amounts of such agents to a population of cells or tissues of a mammal in need thereof.

  本发明涉及利用图像引导能量沉积进行靶向药物输送的组合物和方法，以帮助将活性化合物定位到动物体内特定位置。还提供了这些化合物和制剂，用于将治疗、预防和/或诊断有效剂量的这些药物靶向地输送到需要的哺乳动物的细胞或组织群体中。
• Spergualin-related compounds, processes for the preparation thereof and their use as medicaments
  申请人：MICROBIAL CHEMISTRY RESEARCH FOUNDATION

  公开号：EP0105193A2

  公开（公告）日：1984-04-11

  This invention relates to novel spergualin-related compounds of the formula (I) wherein R1 represents a hydrogen atom, a hydroxyl group, or an aliphatic acyloxy group with 1 to 10 carbon atoms; R2 represents a residue of an a- or ω-amino acid remaining after removing one of the hydrogen atoms from the a- or ω-amino group and the hydroxyl group from the a-carboxyl group with the proviso that R2 does not include a residue of a-hydroxyglycine, said R2 being attached to the adjacent carbonyl group and amino group by amide bonds; and m denotes an integer of 4 to 6, and their physiologically acceptable salts, and to a process for preparing the same. The compounds according to the present invention exhibit high stability and antitumor activity.

  本发明涉及式 (I) 的新型 spergualin 相关化合物 其中 R1 代表氢原子、羟基或具有 1 至 10 个碳原子的脂肪族酰氧基；R2 代表从 a-或 ω-氨基中去除一个氢原子和从 a-羧基中去除羟基后剩余的 a-或 ω-氨基酸残基，但 R2 不包括 a-羟基甘氨酸残基，所述 R2 通过酰胺键连接到相邻的羰基和氨基上；和 m 表示 4 至 6 的整数，以及它们的生理上可接受的盐和制备它们的工艺。本发明的化合物具有高稳定性和抗肿瘤活性。
• Polypeptides, methods for their preparation, pharmaceutical compositions comprising them and use
  申请人：Eisai Co., Ltd.

  公开号：EP0333071A2

  公开（公告）日：1989-09-20

  A polypeptide is shown with the following formula: wherein A, B, C, D, E, F and R1 are as defined in claim 1. The invention includes pharmaceutical compositions comprising the above polypeptide and the use of this polypeptide. Finally, preparation methods for the new polypeptide are disclosed.

  一种多肽如下式所示： 其中 A、B、C、D、E、F 和 R1 如权利要求 1 所定义。 本发明包括包含上述多肽的药物组合物以及该多肽的用途。最后，本发明还公开了新多肽的制备方法。
• Fibrinogen receptor antagonists
  申请人：MERCK & CO. INC.

  公开号：EP0422938A1

  公开（公告）日：1991-04-17

  A fibrinogen receptor antagonist of the formula wherein XX represents a synthetic alpha-amino acid containing a linear side chain and ZZ represents a sequence of 1, 2, 3 or 4 amino acids.

  式中的纤维蛋白原受体拮抗剂 其中 XX 代表含有线性侧链的合成α-氨基酸，ZZ 代表 1、2、3 或 4 个氨基酸的序列。
• Novel spergualin-related compound and use thereof
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：EP0467280A1

  公开（公告）日：1992-01-22

  Novel spergualin-related compounds represented by the general formula (I): wherein X represents -(CH2)1 -5- or a phenylene group which may be substituted; m represents 0, 1 or 2; n represents 1 or 2; and R1 represents -(CH2)1 -3-COOH, and pharmacologically acceptable salts thereof, possess an immunopotentiating activity, and are expected to be useful as immunopotetiators applicable to warm blooded animals.

  通式(I)所代表的新型 spergualin 相关化合物： 其中 X 代表-(CH2)1-5-或可被取代的亚苯基；m 代表 0、1 或 2；n 代表 1 或 2；以及 R1 代表-(CH2)1-3-COOH 及其药理学上可接受的盐类，具有免疫增强活性，有望用作适用于温血动物的免疫诱导剂。