Potassium; 6-amino-6-carboxy-2-oxo-hexanoate | 142055-42-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Potassium; 6-amino-6-carboxy-2-oxo-hexanoate
• CAS: 142055-42-3
• 化学式: C₇H₁₀NO₅*K
• 分子量: 227.258
• InChiKey: DOMIEAFAZYPRFB-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -5.11
• 重原子数：
  14.0
• 可旋转键数：
  6.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  120.52
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  dimethyl (2R,6S)-piperidine-2,6-dicarboxylate 在 Amberlite IR-45 (hydroxide form) 、 potassium tert-butylate 作用下， 反应 24.0h， 生成 Potassium; 6-amino-6-carboxy-2-oxo-hexanoate
  参考文献：
  名称：

  Synthesis of the potassium salt of 2,3,4,5-tetrahydrodipicolinic acid, a key intermediate in the diaminopimelate pathway to L-lysine

  摘要：

  The potassium salt (13) of 2,3,4,5-tetrahydrodipicolinic acid, a key intermediate in the diaminopimelate (DAP) pathway to L-lysine (7), has been prepared by elimination of p-toluenesulphinic acid from the N-toluenesulphonyl derivative (12) of dimethyl cis-piperidine-2,6-dicarboxylate with simultaneous cleavage of the ester groups. 2,3,4,5-Tetrahydrodipicolinic acid exists in solution in equilibrium with the corresponding enamine (15) and an open chain form (14), and serves as a substrate for meso-DAP dehydrogenase on the biosynthetic pathway to L-lysine (7).

  DOI：

  10.1016/s0040-4039(00)79065-4