| 1048333-90-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• CAS: 1048333-90-9
• 化学式: C₂₄H₁₇Cl₄N₃S
• 分子量: 521.297
• InChiKey: AIHBOVCFLFOJAW-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  、 丙炔酸乙酯 以 丁酮 为溶剂， 以53%的产率得到ethyl (Z)-4-(3,4-dichlorobenzyl)amino-5-(2-ethoxycarbonylvinylthio)-1-phenyl-1H-pyrrole-3-carboxylate
  参考文献：
  名称：

  Solvent controlled divergent syntheses of polysubstituted pyrroles and pyrrolo[2,3-b]-1,4-thiazines

  摘要：

  The reaction of 2-imidazolyl carbene-derived 2-arylthiocarbamoyl imidazolium salts with ethyl propiolate proceeded via the solvent dependent tandem [3+2] cycloaddition and subsequent ring transformation processes. While the reaction in butanone yielded 3-amino-2-vinylthiopyrroles as the major products, use of benzene as the solvent led to the predominant formation of pyrrolo[2,3-b][1,4]thiazines. This work disclosed a unique ring transformation of imidazoline-spiro-pyrrolines to pyrFOIO[2,3b][1,4]-thiazines, which provides a simple route to both multifunctional pyrroles and pyrrolo[2,3b][1,4]thiazines that are other-wise difficult to synthesize. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.05.044