Cu(2,2′:6′,2″-terpyridine)(ClO₄)₂(H₂O) | 25970-67-6

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: Cu(2,2′:6′,2″-terpyridine)(ClO₄)₂(H₂O)
• 英文别名: [Cu(II)(2,2':6',6''-terpyridine)(H2O)(ClO4)2]；[Cu(II)(tpy)(H2O)(ClO4)2]
• CAS: 25970-67-6；602269-68-1；602269-70-5
• 化学式: C₁₅H₁₃Cl₂CuN₃O₉
• 分子量: 513.735
• InChiKey: ACYXJEPTJCTTQD-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  α,α,α-三联吡啶 、 copper(II) perchlorate hexahydrate 以 甲醇 为溶剂， 生成 Cu(2,2′:6′,2″-terpyridine)(ClO₄)₂(H₂O)
  参考文献：
  名称：

  The adsorption of 2,2′:6′,2″-terpyridine, 4′-(5-mercaptopentyl)-2,2′:6′,2″-terpyridinyl, and perchlorate on silver and copper surfaces monitored by SERS

  摘要：

  The adsorption of 2,2':6',2"-terpyridine on Ag and Cu electrode surfaces has been studied by using surface enhanced Raman spectroscopy (SERS). Two types of surface complexes have been found on a silver electrode: the first one is stable near the open circuit potential, having bonding between tpy and silver active site analogous to the Ag-N bonding in the [Ag-1(tpy)Cl].2H(2)O complex; and the second one is stable in the -0.1 to -0.5 V (Ag/AgCl) potential range, where the interaction between tpy and silver active site is similar to the Cu-N bonding in the [Cu-II(tpy)Cl-2] complex. The SERS spectra of 4'-(5-mercaptopentyl)-2,2':6',2"-terpyridinyl (tpy-SH) have shown an increase in the relative intensity of the mercaptopentyl moiety bands and a band at 310 cm(-1), assigned to the AgS stretching, indicating an adsorption through the S atom. In addition, using the Raman results of different copper perchlorate salts obtained with different hydration degrees, it has been possible to characterize the adsorption of perchlorate anion on silver electrode and the kind of coordination in the [Cu-II(tpy)(H2O)(ClO4)]ClO4 and [Cu-II(tpy)(H2O)(ClO4)(2)] complexes. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0277-5387(03)00325-5

文献信息

• Synthesis, cytotoxic activity and DNA-binding properties of copper(II) complexes with terpyridine
  作者：Biljana Đ. Glišić、Jasmina Nikodinovic-Runic、Tatjana Ilic-Tomic、Hubert Wadepohl、Aleksandar Veselinović、Igor M. Opsenica、Miloš I. Djuran

  DOI：10.1016/j.poly.2017.11.008

  日期：2018.1

  Abstract Mononuclear copper(II) complexes with 2,2′:6′,2″-terpyridine (terpy), [Cu(terpy)(ClO4)2(H2O)] (1) and [Cu(terpy)2](CF3SO3)2·2H2O (2), were synthesized and structurally characterized by UV–Vis and IR spectroscopy, ESI mass spectrometry and single-crystal X-ray diffraction analysis. In vitro study of cytotoxicity of the complexes demonstrated good antiproliferative properties in the case of human

  摘要具有2,2'：6'，2″-吡啶（叔丁基），[Cu（叔丁基）（ClO4）2（H2O）]（1）和[Cu（terpy）2]（CF3SO3）的单核铜（II）配合物）2·2 （2）是合成的，并通过UV-Vis和IR光谱，ESI质谱和单晶X射线衍射分析对其结构进行了表征。在人非小细胞肺癌（A549）以及肺成纤维细胞（MRC5）细胞系中，对复合物的细胞毒性进行的体外研究显示出良好的抗增殖特性。具有三联吡啶的铜（II）配合物显示出与高分子量双链DNA相互作用的显着能力，而不会引起DNA损伤。另一方面，它们在不存在助氧化剂的情况下引起了质粒DNA的切口，表明中等的溶核活性。圆二色性光谱证实了复合物插入双链DNA。分子对接研究还表明，该复合物与DNA具有很强的结合亲和力，揭示了两种形式的1（分别具有和不具有高氯酸根离子的1a和1b）和2与DNA的主要沟结合。