N-[amino-(4-methoxyphenyl)-oxo-lambda6-sulfanylidene]-4-methylbenzenesulfonamide | 1246403-72-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[amino-(4-methoxyphenyl)-oxo-lambda6-sulfanylidene]-4-methylbenzenesulfonamide
• 英文别名: N-[amino-(4-methoxyphenyl)-oxo-λ6-sulfanylidene]-4-methylbenzenesulfonamide
• CAS: 1246403-72-4
• 化学式: C₁₄H₁₆N₂O₄S₂
• 分子量: 340.424
• InChiKey: ROBFYGPADXUSIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  116
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  苯乙烯 、 N-[amino-(4-methoxyphenyl)-oxo-lambda6-sulfanylidene]-4-methylbenzenesulfonamide 在 tetrakis(actonitrile)copper(I) hexafluorophosphate 、 亚碘酰苯 作用下， 以 乙腈 为溶剂， 以86%的产率得到N-[(4-methoxyphenyl)-oxo-(2-phenylaziridin-1-yl)-lambda6-sulfanylidene]-4-methylbenzenesulfonamide
  参考文献：
  名称：

  Catalytic stereoselective alkene aziridination with sulfonimidamides

  摘要：

  Diastereoselective copper-catalyzed alkene aziridination has been investigated using chiral nitrenes generated from sulfonimidamides in the presence of an iodine(III) oxidant. Starting from a stoichiometric amount of the substrates, the corresponding aziridines were isolated with excellent yields of up to 96%. Good levels of asymmetric induction were obtained in the case of electron-poor olefins, with an optimal de of 94% being reached starting from tert-butyl acrylate. Matching and mismatching effects were also observed upon the use of chiral copper catalysts for the aziridination of styrene. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.03.032