(2S)-2-amino-N-[(3S,4R)-4-hydroxyoxolan-3-yl]-4-methylpentanamide | 215940-75-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-amino-N-[(3S,4R)-4-hydroxyoxolan-3-yl]-4-methylpentanamide
• CAS: 215940-75-3
• 化学式: C₁₀H₂₀N₂O₃
• 分子量: 216.28
• InChiKey: CJWLXZSJAFLPJR-CIUDSAMLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  84.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2S)-2-amino-N-[(3S,4R)-4-hydroxyoxolan-3-yl]-4-methylpentanamide 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 Quinoline-2-carboxylic acid [(S)-3-methyl-1-((S)-4-oxo-tetrahydro-furan-3-ylcarbamoyl)-butyl]-amide
  参考文献：
  名称：

  Diastereoselective synthesis, activity and chiral stability of cyclic alkoxyketone inhibitors of cathepsin K

  摘要：

  The diastereoselective synthesis of a novel class of cathepsin K inhibitors together with their cathepsin K affinity and stability towards aqueous buffer is reported. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(00)00627-2
• 作为产物：
  描述：

  [(S)-1-((3S,4R)-4-Hydroxy-tetrahydro-furan-3-ylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester 在 palladium on activated charcoal 氢气 作用下， 生成 (2S)-2-amino-N-[(3S,4R)-4-hydroxyoxolan-3-yl]-4-methylpentanamide
  参考文献：
  名称：

  Diastereoselective synthesis, activity and chiral stability of cyclic alkoxyketone inhibitors of cathepsin K

  摘要：

  The diastereoselective synthesis of a novel class of cathepsin K inhibitors together with their cathepsin K affinity and stability towards aqueous buffer is reported. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(00)00627-2

文献信息

• Diastereoselective synthesis, activity and chiral stability of cyclic alkoxyketone inhibitors of cathepsin K
  作者：Ashley E Fenwick、Andrew D Gribble、Robert J Ife、Nichola Stevens、Jason Witherington

  DOI：10.1016/s0960-894x(00)00627-2

  日期：2001.1

  The diastereoselective synthesis of a novel class of cathepsin K inhibitors together with their cathepsin K affinity and stability towards aqueous buffer is reported. (C) 2001 Published by Elsevier Science Ltd.