| 1573112-78-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 1573112-78-3
• 化学式: C₂HF₃O₂*C₂₉H₃₉N₇O₇
• 分子量: 711.695
• InChiKey: SROJRPKYTLFCIG-WWQPDCEASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.68
• 重原子数：
  50.0
• 可旋转键数：
  14.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  253.63
• 氢给体数：
  7.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  在 N-甲基吗啉 作用下， 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Facile solid phase synthesis of N-cycloguanidinyl-formyl peptides

  摘要：

  A novel strategy of solid phase synthesis of N-cycloguanidinyl-formyl peptides has been established and investigated which involved coupling orthogonal protected diaminoacid with resin bound peptide, alpha-amino group deprotection, guanidinylation of alpha-amino group by bis-Cbz-1H-pyrazole-1-carboxamidine followed by cleavage and cyclization in solution, and finally removing Cbz by palladium catalyzed hydrogenation. Through this method, cycloguanidine could be introduced to either N-terminus or side-chain of designated peptides. The reaction conditions were facile, straightforward, and totally adaptive to common solid phase peptide synthesis strategy. (c) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.01.100