精氨酰氧肟酸 | 5699-67-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 精氨酰氧肟酸
• 中文别名: 5-乙基-5-(3-羟基苯基)嘧啶-2,4,6(1H,3H,5H)-三酮
• 英文名称: L-arginine hydroxamate
• 英文别名: 2-Amino-5-guanidino-N-hydroxypentanamide；2-amino-5-(diaminomethylideneamino)-N-hydroxypentanamide
• CAS: 5699-67-2
• 化学式: C₆H₁₅N₅O₂
• 分子量: 189.217
• InChiKey: IXHTVNGQTIZAFS-UHFFFAOYSA-N

物化性质

• 密度：
  1.53±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  140
• 氢给体数：
  5
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(3-{(1R,4R,6R,9R)-9-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-6-hydroxy-3-[(Z)-hydroxyimino]-2,8-dioxa-5-aza-bicyclo[4.3.1]dec-4-yl}-propyl)-guanidine 在 三氟乙酸 作用下， 以5 mg的产率得到精氨酰氧肟酸
  参考文献：
  名称：

  Cytosine glycosides from Streptomyces griseochromogenes

  摘要：

  On supplementation of fermentations of Streptomyces griseochromogenes, an organism that produces the anti-fungal antibiotic blasticidin S (BS), with L-arginine hydroxamate in order to block the de novo biosynthesis of L-arginine, an essential precursor for BS, the accumulation of five new metabolites resulted. These new metabolites were purified by ion exchange chromatography and HPLC, and were characterized by NMR and mass spectroscopy and by chemical degradation. Two are normally very minor metabolites of S. griseochromogenes, while the other three are derived in part from the inhibitor that had been added to the fermentation.

  DOI：

  10.1016/s0031-9422(00)95133-1

文献信息

• HUMAN ADAM-10 INHIBITORS
  申请人：Exelixis, Inc.

  公开号：EP1461313A1

  公开（公告）日：2004-09-29
• [EN] HUMAN ADAM-10 INHIBITORS<br/>[FR] INHIBITEURS DE L'ADAM-10 HUMAINE
  申请人：EXELIXIS INC

  公开号：WO2003051825A1

  公开（公告）日：2003-06-26

  The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chorides and ADAM-10 modulators therefrom.