4-(3-{4-[(2,6-dimethylphenylcarbamoyl)-methyl]-piperazin-1-yl}-2-hydroxy-propoxy)-1H-indole-2-carboxylic acid amide | 449756-39-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-(3-{4-[(2,6-dimethylphenylcarbamoyl)-methyl]-piperazin-1-yl}-2-hydroxy-propoxy)-1H-indole-2-carboxylic acid amide
• 英文别名: 4-(3-{4-[(2,6-dimethylphenylcarbamoyl)-methyl]-piperazin-1-yl}-2-hydroxypropoxy)-1H-indole-2-carboxamide；4-[3-[4-[2-(2,6-dimethylanilino)-2-oxoethyl]piperazin-1-yl]-2-hydroxypropoxy]-1H-indole-2-carboxamide
• CAS: 449756-39-2
• 化学式: C₂₆H₃₃N₅O₄
• 分子量: 479.579
• InChiKey: ZHRAGUPUYMHBFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Heteroaryl alkyl piperazine derivatives
  申请人：——

  公开号：US20030216409A1

  公开（公告）日：2003-11-20

  Novel compounds of the general formula: 1 and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subsequent to muscle or systemic diseases such as intermittent claudication, to treat shock conditions, to preserve donor tissue and organs used in transplants, in the treatment of diabetes, in the treatment of cardiovascular diseases including atrial and ventricular arrhythmias, Prinzmetal's (variant) angina, stable angina, and exercise induced angina, congestive heart disease, and myocardial infarction.

  通用公式：1的新化合物及其药学上可接受的酸盐，其中这些化合物在治疗中用于保护骨骼肌免受外伤引起的损伤或在骨骼肌或系统性疾病（如间歇性跛行）后保护骨骼肌，用于治疗休克状态，保护供体组织和器官用于移植，治疗糖尿病，治疗心血管疾病，包括心房和心室心律失常，普林兹梅塔（变异）心绞痛，稳定型心绞痛和运动诱发性心绞痛，充血性心脏病和心肌梗死。
• HETEROARYL ALKYL PIPERAZINE DERIVATIVES AS FATTY ACID OXIDATION INHIBITORS
  申请人：CV THERAPEUTICS, INC.

  公开号：EP1339701A1

  公开（公告）日：2003-09-03
• US6849632B2
  申请人：——

  公开号：US6849632B2

  公开（公告）日：2005-02-01
• [EN] HETEROARYL ALKYL PIPERAZINE DERIVATIVES AS FATTY ACID OXIDATION INHIBITORS<br/>[FR] DERIVES D'HETEROARYLE ALKYLE PIPERAZINE SERVANT D'INHIBITEURS DE L'OXYDATION DES ACIDES GRAS
  申请人：CV THERAPEUTICS INC

  公开号：WO2002064576A1

  公开（公告）日：2002-08-22

  Novel compounds of the general formula (I): and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subsequent to muscle or systemic diseases such as intermittent claudication, to treat shock conditions, to preserve donor tissue and organs used in transplants, in the treatment of cardiovascular diseases including atrial and ventricular arrhythmias, Prinzmetal's (variant) angina, stable angina, and exercise induced angina, congestive heart disease, and myocardial infarction.