2-propyloct-7-enoic acid | 161090-05-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-propyloct-7-enoic acid
• 英文别名: 2-propyl-7-octenoic acid
• CAS: 161090-05-7
• 化学式: C₁₁H₂₀O₂
• 分子量: 184.279
• InChiKey: HDSNNKRZCIRTCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-propyloct-7-enoic acid 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 20.25h， 生成 ethyl (2S,5S,E)- 7-((2,4-dimethoxybenzyl)(methyl)carbamoyl)-2-isobutyl-3,16-dioxo-15-propyl-1,4-diazacyclohexadec-9-ene-5-carboxylate
  参考文献：
  名称：

  [EN] PEPTIDOMIMETIC N5-METHYL-N2-(NONANOYL-L-LEUCYL)-L-GLUTAMINATE DERIVATIVES, TRIAZASPIRO[4.14]NONADECANE DERIVATIVES AND SIMILAR COMPOUNDS AS INHIBITORS OF NOROVIRUS AND CORONAVIRUS REPLICATION
  [FR] DÉRIVÉS DE N5-MÉTHYL-N2-(NONANOYL-L-LEUCYL)-L-GLUTAMINATE PEPTIDOMIMÉTIQUES, DÉRIVÉS DE TRIAZASPIRO[4.14]NONADÉCANE ET COMPOSÉS SIMILAIRES UTILISÉS EN TANT QU'INHIBITEURS DE RÉPLICATION DE NOROVIRUS ET DE CORONAVIRUS

  摘要：

  肽拟态N5-甲基-N2-(壬酰基-L-亮氨酰基)-L-谷氨酸衍生物，三唑螺[4.14]十九烷衍生物以及类似化合物用于抑制生物样本或患者中诺如病毒和冠状病毒的复制，用于减少生物样本或患者中诺如病毒或冠状病毒的数量，以及用于治疗患者中的诺如病毒和冠状病毒，包括向所述生物样本或患者施用由公式I或II表示的化合物的安全有效量，或其药用可接受盐。本描述公开了典型化合物的合成和特性，以及其药理数据（例如，第99页至第271页；例1至例3；化合物A1至A104和B1至B66；表A至表E）。

  公开号：

  WO2021188620A1

文献信息

• [EN] SULFONATED ORGANOPHOSPHINE COMPOUNDS AND USE THEREOF IN HYDROFORMYLATION PROCESSES<br/>[FR] COMPOSÉS D'ORGANOPHOSPHINE SULFONÉE ET LEUR UTILISATION DANS DES PROCÉDÉS D'HYDROFORMYLATION
  申请人：DOW GLOBAL TECHNOLOGIES INC

  公开号：WO2009091671A1

  公开（公告）日：2009-07-23

  A compound comprising a sulfonated triorganophosphine of formula R1R2PR3[SO3M)]n, wherein R1 and R2 are selected individually from alkyl, aralkyl, and alicyclic groups; wherein R3 represents a branched divalent or polyvalent, alkylene or alicyclic radical that is bonded to the phosphorus atom and to one or more sulfonate substituents, and further wherein R3 does not contain any aryl moieties; M represents a monovalent cation; and n is an integer representing a total number of sulfonated substituents. The compound is useful as a ligand in transition metal-ligand complex catalysts that are capable of catalyzing the hydroformylation of an olefinically-unsaturated compound with carbon monoxide and hydrogen to form one or more corresponding aldehyde products. The ligand is incapable of alkyl-aryl exchange, thereby leading to reduced ligand usage and improving ligand and transition metal, e.g., rhodium, recovery and recycling, as compared with prior art ligands.

  一种化合物，包括公式R1R2PR3[SO3M)]n的磺化三有机膦，其中R1和R2分别从烷基、芳基烷基和脂环基中选择；其中R3代表与磷原子和一个或多个磺酸取代基结合的支链二价或多价、烷基或脂环基团，且R3不含任何芳基；M代表一价阳离子；n是表示磺化取代基总数的整数。该化合物可用作过渡金属-配体复合催化剂中的配体，能够催化烯烃不饱和化合物与一氧化碳和氢反应，形成一个或多个相应的醛产物。该配体无法进行烷基-芳基交换，从而减少配体的使用量，改善配体和过渡金属（例如铑）的回收和循环，与现有技术的配体相比。
• Asymmetric catalysts prepared from optically active bisphosphites bridged by achiral diols
  申请人：——

  公开号：US20040199023A1

  公开（公告）日：2004-10-07

  This invention relates to asymmetric hydroformylation (hf) processes in which a prochiral or chiral compound is contacted in the presence of an optically active metal-ligand complex catalyst to produce an optically active aldehyde or product derived from an optically active aldehyde. The invention encompasses novel ligands and catalysts for use in such processes.

  这项发明涉及不对称氢甲酰化（hf）过程，其中在存在光学活性金属配体复合催化剂的情况下接触一个非手性或手性化合物，以产生一个光学活性的醛或源自光学活性醛的产物。该发明涵盖了用于此类过程的新型配体和催化剂。
• [EN] SULFONATED ORGANOPHOSPHINE COMPOUNDS AND USE IN HYDROFORMYLATION PROCESSES<br/>[FR] COMPOSÉS D'ORGANOPHOSPHINE SULFONÉE ET LEUR UTILISATION DANS LES PROCESSUS D'HYDROFORMYLATION
  申请人：DOW GLOBAL TECHNOLOGIES INC

  公开号：WO2009091669A1

  公开（公告）日：2009-07-23

  A compound comprising a sulfonated dihydrocarbyl(arylalkyl)phosphine of formula R1R2PR3-(SO3M)n, wherein the R1 and R2 are selected individually from alkyl, aralkyl, and alicyclic groups, and R3 is a divalent or polyvalent arylalkylene radical such that the alkyl moiety is bonded to the phosphorus atom and the aryl moiety is bonded to the alkyl and is also substituted with one or more sulfonate groups; M is a monovalent cation, and n ranges from 1 to 3. The compound is useful as a ligand in transition metal-ligand complex catalysts that are capable of catalyzing the hydroformylation of an olefinically-unsaturated compound with carbon monoxide and hydrogen to form one or more corresponding aldehyde products. The ligand is incapable of alkyl-aryl exchange, thereby leading to reduced ligand usage and improved ligand and transition metal, e.g., rhodium, recovery and recycling.

  一种化合物，包含磺化的二烃基(芳烷基)膦，其化学式为R1R2PR3-(SO3M)n，其中R1和R2各自独立地选自烷基、芳烷基和脂环族基团，R3为二价或多价的芳烷基二价基团，使得烷基部分与磷原子相连，芳基部分与烷基相连，并且还带有一个或多个磺酸基团；M为单价阳离子，n的范围为1至3。该化合物作为配体在过渡金属-配体复合催化剂中具有应用价值，这些催化剂能够催化烯烃不饱和化合物与一氧化碳和氢气反应生成一个或多个相应的醛类产物。该配体不具备烷基-芳基交换能力，从而减少了配体的使用量，并提高了配体和过渡金属（例如铑）的回收和再循环效率。
• [EN] STABILIZATION OF A HYDROFORMYLATION PROCESS<br/>[FR] STABILISATION D'UN PROCEDE D'HYDROFORMYLATION
  申请人：UNION CARBIDE CHEM PLASTIC

  公开号：WO2006020287A1

  公开（公告）日：2006-02-23

  A hydroformylation process having improved stability involving reacting one or more reactants, such as an olefin, with carbon monoxide and hydrogen in the presence of a hydroformylation catalyst, to produce a reaction product fluid comprising one or more products, preferably aldehydes; wherein said process is conducted in a region of the hydroformylation rate curve that is negative or inverse order in carbon monoxide; and wherein total pressure is controlled at a predetermined target value and/or vent flow rate is controlled at a predetermined target value, by adjusting a flow of a carbon-monoxide containing inlet gas, so as to prevent sudden changes and/or lessen cycling of process parameters, for example, reaction rate, total pressure, vent flow rate, temperature, or a combination thereof.

  一种具有改善稳定性的氢甲酰化工艺，涉及在氢甲酰化催化剂存在下，将一个或多个反应物（如烯烃）与一氧化碳和氢气反应，生成包括一个或多个产物（最好是醛类）的反应产物流体；其中该工艺在氢甲酰化速率曲线的负或反向碳一氧化物顺序区域中进行；总压力控制在预定目标值，和/或通风流速控制在预定目标值，通过调整含一氧化碳的进气气体流量，以防止过程参数（例如反应速率、总压力、通风流速、温度或其组合）的突然变化和/或减少循环。
• [EN] HYDROFORMYLATION PROCESS WITH A DOUBLY OPEN-ENDED BISPHOSPHITE LIGAND<br/>[FR] PROCEDE D'HYDROFORMYLATION AVEC UN LIGAND BISPHOSPHITE A DOUBLE EXTREMITE OUVERTE
  申请人：DOW TECHNOLOGY INVESTMENTS LLC

  公开号：WO2010117391A1

  公开（公告）日：2010-10-14

  A continuous hydroformylation process for producing at least one aldehyde product by utilizing a transition metal and a ligand mixture comprising an organopolyphosphite and an organomonophosphine, with improved stability of the organopolyphosphite ligand. The process involves reacting one or more olefinically-unsaturated compounds with carbon monoxide and hydrogen in the presence of an organopolyphosphite ligand and an organomonophosphine ligand, at least one of such ligands being bonded to a transition metal to form a transition metal-ligand complex hydroformylation catalyst. Surprisingly the addition of the organomonophosphine to a Rh/organopolyphosphite catalyst system did not result in a significant loss of reaction rate.

  通过利用过渡金属和配体混合物，包括有机聚磷酸酯和有机单磷酸酯，生产至少一种醛产品的连续氢甲酰化过程，提高了有机聚磷酸酯配体的稳定性。该过程涉及在有机聚磷酸酯配体和有机单磷酸酯配体的存在下，将一种或多种烯烃未饱和化合物与一氧化碳和氢气反应，其中至少一种配体与过渡金属结合以形成过渡金属-配体复合物氢甲酰化催化剂。令人惊讶的是，在Rh/有机聚磷酸酯催化剂体系中添加有机单磷酸酯并未导致反应速率显著下降。