糖精 | 714229-20-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 糖精
• 英文名称: Advantame
• 英文别名: (3S)-3-[3-(3-hydroxy-4-methoxyphenyl)propylamino]-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid;hydrate
• CAS: 714229-20-6
• 化学式: C24H32N2O8
• 分子量: 476.5
• InChiKey: NQQIEOGMDRFTDZ-HLRBRJAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.84
• 重原子数：
  34
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  135
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• CRYSTAL OF MULTIVALENT METAL SALT OF MONATIN
  申请人：MORI Kenichi

  公开号：US20130011538A1

  公开（公告）日：2013-01-10

  To provide a novel monatin crystal capable of forming a sweetener composition which is less likely to be degraded even when being exposed to high temperature and high humidity conditions in the coexistence of a reducing sugar. It was found that the object can be achieved by a crystal of a multivalent metal salt of (2R,4R)-monatin.

  提供一种新型的莫纳丁晶体，能够形成甜味剂组合物，即使在存在还原糖的高温高湿条件下也不太可能被降解。发现通过(2R,4R)-莫纳丁的多价金属盐晶体可以实现这一目标。
• Hydrate crystals of (2R,4R)-Monatin monosodium salt
  申请人：Ajinomoto Co., Inc.

  公开号：EP2107053A1

  公开（公告）日：2009-10-07

  An object of the present invention is to provide general-purpose, stable, and safe monatin sodium salt crystals incorporating no organic solvent. A further object is to provide a manufacturing method that requires no organic solvent in the crystallization, separation, and drying steps. A still further object is to clarify the utility and physical properties of these stereoisomers as sweeteners. And a still further object is to provide orally consumed products, such as foods, beverages, pharmaceutical products, topical pharmaceutical products, and feeds containing general-purpose, stable, and safe monatin sodium salt crystals. It has been discovered that the above objects are achieved by new (2R,4R) monatin monosodium salt hydrate crystals characterized by having specific characteristic X-ray diffraction peaks.

  本发明的目的是提供一种通用、稳定、安全的莫纳丁钠盐晶体，不含有机溶剂。另一个目的是提供一种制造方法，该方法在结晶、分离和干燥步骤中不需要有机溶剂。还有一个目的是澄清这些立体异构体作为甜味剂的效用和物理性质。另一个目的是提供口服产品，如食品、饮料、制药产品、局部制药产品和饲料，其中包含通用、稳定、安全的莫纳丁钠盐晶体。已经发现上述目的是通过具有特定特征X射线衍射峰的新的（2R,4R）莫纳丁单钠盐水合物晶体实现的。
• HYDRATE CRYSTALS
  申请人：MORI Kenichi

  公开号：US20090318528A1

  公开（公告）日：2009-12-24

  New (2R,4R) monatin monosodium salt hydrate crystals characterized by having specific characteristic X-ray diffraction peaks provide general-purpose, stable, and safe monatin sodium salt crystals incorporating no organic solvent. These crystal may be prepared by a method that requires no organic solvent in the crystallization, separation, and drying steps. These crystal are useful as sweeteners and for the preparation of orally consumed products, such as foods, beverages, pharmaceutical products, topical pharmaceutical products, and feeds containing general-purpose, stable, and safe monatin sodium salt crystals.
• US7973070B2
  申请人：——

  公开号：US7973070B2

  公开（公告）日：2011-07-05