N-[3,4-bis(difluoromethoxy)benzyl]-2-methylpropane-2-sulfinamide | 1112851-47-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-[3,4-bis(difluoromethoxy)benzyl]-2-methylpropane-2-sulfinamide
• 英文别名: N-[[3,4-bis(difluoromethoxy)phenyl]methyl]-2-methylpropane-2-sulfinamide
• CAS: 1112851-47-4
• 化学式: C₁₃H₁₇F₄NO₃S
• 分子量: 343.342
• InChiKey: XWCAGWRBEJXHCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  N-[3,4-bis(difluoromethoxy)benzyl]-2-methylpropane-2-sulfinamide 在 盐酸 作用下， 以 甲醇 、 乙醚 为溶剂， 反应 0.5h， 生成 [3,4-双(二氟甲氧基)苯基]甲胺盐酸盐
  参考文献：
  名称：

  TRIPYRIDYL CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS

  摘要：

  本发明涉及三吡啶基羧酰胺化合物，它们是促进睡眠的受体拮抗剂，可用于治疗或预防涉及促进睡眠的神经和精神障碍和疾病。该发明还涉及包含这些化合物的药物组合物，以及在预防或治疗涉及促进睡眠的这类疾病中使用这些化合物和组合物。

  公开号：

  US20100035931A1
• 作为产物：
  描述：

  3,4-双(二氟甲氧基)苯甲醛 、 叔丁基亚磺酰胺 在 titanium(IV) tetraethanolate 、 sodium tetrahydroborate 、 甲醇 作用下， 以 四氢呋喃 为溶剂， 反应 4.5h， 生成 N-[3,4-bis(difluoromethoxy)benzyl]-2-methylpropane-2-sulfinamide
  参考文献：
  名称：

  TRIPYRIDYL CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS

  摘要：

  本发明涉及三吡啶基羧酰胺化合物，它们是促进睡眠的受体拮抗剂，可用于治疗或预防涉及促进睡眠的神经和精神障碍和疾病。该发明还涉及包含这些化合物的药物组合物，以及在预防或治疗涉及促进睡眠的这类疾病中使用这些化合物和组合物。

  公开号：

  US20100035931A1

文献信息

• PYRIDINE CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS
  申请人：Bergman Jeffrey M.

  公开号：US20100197652A1

  公开（公告）日：2010-08-05

  The present invention is directed to pyridyl carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明针对吡啶基羧酰胺化合物，该化合物是促进睡眠激素受体的拮抗剂，可用于治疗或预防神经和精神障碍以及涉及促进睡眠激素受体的疾病。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗涉及促进睡眠激素受体的疾病中使用这些化合物和组合物的用途。
• Pyridine Carboxamide orexin Receptor Antagonists
  申请人：Bergman Jeffrey M.

  公开号：US20110301140A1

  公开（公告）日：2011-12-08

  The present invention is directed to pyridyl carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及吡啶基羧酰胺化合物，其是促睡素受体的拮抗剂，可用于治疗或预防神经系统和精神疾病，以及促睡素受体参与的疾病。本发明还涉及包含这些化合物的制药组合物以及这些化合物和组合物在预防或治疗促睡素受体参与的疾病中的使用。
• 2,5-Disubstituted Phenyl Carboxamide Orexin Receptor Antagonists
  申请人：Bergman Jeffrey M.

  公开号：US20110207747A1

  公开（公告）日：2011-08-25

  The present invention is directed to 2,5-disubstituted phenyl carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及2,5-二取代苯基羧酰胺化合物，其为促进睡眠的药物，可以用于治疗或预防神经学和精神疾病，以及涉及促进睡眠的疾病。本发明还涉及包含这些化合物的制药组合物以及这些化合物和组合物在涉及促进睡眠的疾病的预防或治疗中的使用。
• Pyridine carboxamide orexin receptor antagonists
  申请人：Merck Sharp & Dohme Corp.

  公开号：US08003797B2

  公开（公告）日：2011-08-23

  The present invention is directed to pyridyl carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及吡啶基羧酰胺化合物，其是促进睡眠的荷尔蒙受体拮抗剂，可用于治疗或预防涉及荷尔蒙受体的神经和精神疾病。本发明还涉及包含这些化合物的药物组合物以及在预防或治疗涉及荷尔蒙受体的疾病中使用这些化合物和组合物。
• Tripyridyl carboxamide orexin receptor antagonists
  申请人：Merck Sharp & Dohme Corp.

  公开号：US08349872B2

  公开（公告）日：2013-01-08

  The present invention is directed to tripyridyl carboxamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及三吡啶基羧酰胺化合物，它们是促进睡眠的药物，可用于治疗或预防神经系统和精神疾病，以及涉及促进睡眠的疾病。本发明还涉及包含这些化合物的制药组合物以及在涉及促进睡眠的疾病的预防或治疗中使用这些化合物和组合物。