5,7-nonadienoic acid | 111876-07-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5,7-nonadienoic acid
• 英文别名: (5E,7E)-nona-5,7-dienoic acid
• CAS: 111876-07-4
• 化学式: C₉H₁₄O₂
• 分子量: 154.209
• InChiKey: MBFQFNUNKGVKRZ-MQQKCMAXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5,7-nonadienoic acid 在 草酰氯 、 三乙胺 作用下， 以 甲苯 为溶剂， 生成 (7E,9E)-Undeca-7,9-dien-3-ynoic acid methyl ester
  参考文献：
  名称：

  烯丙酸酯二烯亲分子的分子内Diels-Alder反应

  摘要：

  已经制备了（E，E）-dodeca-2,3,8,10-丁烯酸甲酯和（E，E）-undeca-2,3,7,9-丁烯酸甲酯并显示出它们会发生分子内Diels-Alder反应，后者在环境温度下自然发生。

  DOI：

  10.1039/c39870001449
• 作为产物：
  描述：

  (5E,7E)-Nona-5,7-dienoic acid 在 碘 作用下， 以 四氯化碳 为溶剂， 生成 5,7-nonadienoic acid
  参考文献：
  名称：

  烯丙酸酯二烯亲分子的分子内Diels-Alder反应

  摘要：

  已经制备了（E，E）-dodeca-2,3,8,10-丁烯酸甲酯和（E，E）-undeca-2,3,7,9-丁烯酸甲酯并显示出它们会发生分子内Diels-Alder反应，后者在环境温度下自然发生。

  DOI：

  10.1039/c39870001449

文献信息

• Enantioselective Rhodium-Catalyzed [4+2+2] Cycloaddition of Dienyl Isocyanates for the Synthesis of Bicyclic Azocine Rings
  作者：Robert T. Yu、Rebecca Keller Friedman、Tomislav Rovis

  DOI：10.1021/ja906641d

  日期：2009.9.23

  A highly enantioselective rhodium-catalyzed [4+2+2] cycloaddition of terminal alkynes and dienyl isocyanates has been developed. The cycloaddition provides a rapid entry to highly functionalized and enantioenriched bicyclic azocines. This reaction represents the first [4+2+2] cycloaddition strategy to construct nitrogen-containing eight-membered rings.

  已开发出高度对映选择性铑催化的末端炔烃和二烯基异氰酸酯的 [4+2+2] 环加成反应。环加成提供了快速进入高度官能化和对映体富集的双环偶氮化合物的途径。该反应代表了构建含氮八元环的第一个 [4+2+2] 环加成策略。
• Molecular design of diene monomers containing an ester functional group for the synthesis of poly(diene sulfone)s by radical alternating copolymerization with sulfur dioxide
  作者：Akikazu Matsumoto、Sungi Lee、Haruyuki Okamura

  DOI：10.1002/pola.27528

  日期：2015.4.15

  Functional poly(diene sulfone)s are prepared by the radical alternating copolymerization of 1,3‐diene monomers containing an ester substituent with sulfur dioxide. Methyl 3,5‐hexadienoate (MH) and methyl 5,7‐octadienoate (MO) with both an alkylene spacer and a terminal diene structure are suitable to produce a high‐molecular‐weight copolymer in a high yield, while the copolymerization of 5,7‐nonadienoic

  功能性聚（二烯砜）是通过将含有酯取代基的1,3-二烯单体与二氧化硫进行自由基交替共聚而制得的。具有亚烷基间隔基和末端二烯结构的3,5-己二酸甲酯（MH）和5,7-辛二烯酸甲酯（MO）适用于高收率地生产高分子量共聚物，而5的共聚包括亚烷基间隔基或末端二烯结构的，7-壬二烯酸，2,4-戊二烯酸乙酯和4-甲基-2-2,4-戊二烯酸乙酯导致未成功的结果。在13MH和MO的C NMR化学位移值表明在它们反应的α碳处具有高电子密度，表现出高共聚反应活性。还制备了含芴的二烯单体9-芴基3,5-己二酸酯（FH）和9-芴基5,7-辛二烯酸酯（FO），并与二氧化硫共聚。研究了在侧链中含有甲基和芴基酯取代基的聚二烯砜的热学和光学性质。©2015 Wiley Periodicals，Inc. J. Polym。科学，A部分：Polym。化学 2015年，53，1000至09年
• HUDLICKY T.; KOSZYK F. J.; DOCHWAT D. M.; CANTRELL G. L., J. ORG. CHEM., 1981, 46, NO 14, 2911-2915
  作者：HUDLICKY T.、 KOSZYK F. J.、 DOCHWAT D. M.、 CANTRELL G. L.

  DOI：——

  日期：——
• BIODEGRADABLE CHEWING GUM BASES AND USES THEREOF
  申请人：Flynn Allison

  公开号：US20110206802A1

  公开（公告）日：2011-08-25

  Biodegradable chewing gum bases containing one or more crosslinked polyesters, and methods of making and using thereof are described herein. In one embodiment, the base contains a first monomer derived from a saturated or unsaturated lipid, such as a saturated or unsaturated hydroxy fatty acid, optionally a second monomer derived from a saturated or unsaturated polyol, such as a saturated or unsaturated polycarboxylic acid or polyhydroxy compound, and optionally a third monomer, such as a saturated or unsaturated monocarboxylic acid, polycarboxylic and/or hydroxy acid having 5 carbons or less. The polyesters can be crosslinked in the presence of a free radical initiator via thermally-initiated or photo-initiated free radical polymerization. The chewing gum bases are rubbery at room temperature, have a low degree of tackiness and have low glass transition temperatures. One or more additive can be incorporated and/or active agents can also be incorporated into the chewing gum base.
• METABOLITE BIOMARKERS FOR THE DETECTION OF LIVER CANCER
  申请人：Purdue Research Foundation

  公开号：US20150133331A1

  公开（公告）日：2015-05-14

  Methods for the detection and screening of hepatocellular carcinoma (HCC) patients and for the monitoring of HCC treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. In other aspects, methods for detection and screening for the progression of high-risk conditions, such as HCV infections, to HCC and to monitoring treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. The biomarkers are sensitive and specific for the detection of HCC, and can also be used to classify HCV infections that are regarded as precursors of HCC.