prop-2-yn-1-yl-4-cyano-4-(((ethylthio)-carbonothioyl)thio)pentanoate | 1421706-03-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: prop-2-yn-1-yl-4-cyano-4-(((ethylthio)-carbonothioyl)thio)pentanoate
• CAS: 1421706-03-7
• 化学式: C₁₂H₁₅NO₂S₃
• 分子量: 301.455
• InChiKey: FHJLDTWJVGGMQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.0
• 重原子数：
  18.0
• 可旋转键数：
  6.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  50.09
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  4-氰基-4-(((乙硫基)硫代羰基)硫基)戊酸 、 2-丙炔-1-醇 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以82%的产率得到prop-2-yn-1-yl-4-cyano-4-(((ethylthio)-carbonothioyl)thio)pentanoate
  参考文献：
  名称：

  UV Light and Temperature Responsive Supramolecular ABA Triblock Copolymers via Reversible Cyclodextrin Complexation

  摘要：

  A novel triblock macromolecular architecture based on cyclodextrin (CD) complexation is presented. A CD-functionalized biocompatible poly(N-(2-hydroxypropyI)methacrylamide) (PHPMA) building block (3800 <= M-n <= 10 600 g mol(-1) 1.29 <= D-M <= 1.46) and doubly guest-containing poly(N,N-dimethylacrylamide) (PDMAAm) (6400 <= Mn <= 15 700 g mol(-1) 1.06 <= D-M <= 1.15) and poly(N,N-diethylacrylamide) (PDEAAm) (5400 <= M-n <= 12 100 g mol(-1) 1.11 <= D-M <= 1.33) segments were prepared via reversible addition fragmentation chain transfer (RAFT) polymerization and subsequently utilized for the formation of a well-defined supramolecular ABA triblock copolymer. The block formation was evidenced via dynamic light scattering (DLS), nuclear Overhauser effect spectroscopy (NOESY), and turbidity measurements. Furthermore, the connection of the blocks was proven to be temperature responsive and in the case of azobenzene guests responsive to the irradiation with UV light. The application of these stimuli leads to the disassembly of the triblock copolymer, which was shown to be reversible. In the case of PDEAAm containing triblock copolymers, the temperature-induced aggregation was investigated as well.

  DOI：

  10.1021/ma302386w