5,11,17,23-tetra-tert-butyl-25,26,27,28-tetrakis-[(morpholinocarbonyl)-methoxy]-2,8,14,20-tetrathiacalix[4]arene | 1030857-71-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5,11,17,23-tetra-tert-butyl-25,26,27,28-tetrakis-[(morpholinocarbonyl)-methoxy]-2,8,14,20-tetrathiacalix[4]arene
• 英文别名: tetrakis(N-morpholinocarbonylmethoxy)-p-tert-butylthiacalix[4]arene tetracarboxylic acid；1-Morpholin-4-yl-2-[[5,11,17,23-tetratert-butyl-26,27,28-tris(2-morpholin-4-yl-2-oxoethoxy)-2,8,14,20-tetrathiapentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(24),3,5,7(28),9,11,13(27),15(26),16,18,21(25),22-dodecaen-25-yl]oxy]ethanone
• CAS: 1030857-71-6；1042045-22-6；1042045-24-8；1042045-26-0
• 化学式: C₆₄H₈₄N₄O₁₂S₄
• 分子量: 1229.65
• InChiKey: JRHINDKTLPIOID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.5
• 重原子数：
  84
• 可旋转键数：
  16
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  256
• 氢给体数：
  0
• 氢受体数：
  16

反应信息

• 作为产物：
  描述：

  吗啉 、 5,11,17,23-tetra-tert-butyl-25,26,27,28-tetrakis[(chlorocarbonyl)methoxy]-thiacalix[4]arene 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以93%的产率得到5,11,17,23-tetra-tert-butyl-25,26,27,28-tetrakis-[(morpholinocarbonyl)-methoxy]-2,8,14,20-tetrathiacalix[4]arene
  参考文献：
  名称：

  Solvent extraction and self-assembly of nanosized aggregates of p-tert-butyl thiacalix[4]arenes tetrasubstituted at the lower rim by tertiary amide groups and monocharged metal cations in the organic phase

  摘要：

  New p-tent-butyl thiacalix[4]arenes functionalized with morpholide and pyrrolidide groups at the lower rim in cone, partial cone, and 1,3-alternate conformations were synthesized, and their receptor properties for monocharged cations (alkali metal and silver ions) were studied using the picrate extraction method and dynamic light scattering (DLS). To evaluate the ability of the p-tent-butyl thiacalix[4]arene derivatives to recognize metal ions, liquid-liquid extraction of their picrate salts has been carried out in a mutually saturated water-dichloromethane system. The degrees of extraction and the extraction constants for inonocharged metal cations (Li+, Na+, K+, Cs+) have been determined. The ability of the systems, consisting of host and guest molecules, to self-assembly was proved by DLS using a Zetasizer Nano ZS particle size analyzer. It was shown that all the investigated thiacalix[4]arenes are able to form nanoscale particles with silver cations under the experimental conditions. The pyrrolidide derivative in the cone conformation showed both self-association and aggregation processes with lithium cations. The degree of extraction for all the investigated systems that formed nanoscale aggregates in the organic phase was more than 67% and the extraction constants, log K-ex determined by the picrate extraction method, more than 6. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.05.102

文献信息

• Synergistic extraction of cesium, strontium, and europium with adamantylated thiacalix[4]arenes in the presence of chlorinated cobalt dicarbollide
  作者：V. V. Kovalev、E. V. Khomich、E. A. Shokova、V. A. Babain、M. Yu. Alyapyshev

  DOI：10.1134/s1070363208010040

  日期：2008.1

  Synergistic extraction of long-lived fission products 137Cs+, 85Sr2+, and 152Eu3+ from dilute HNO3 into dichloroethane with ligands derived from p-(1-adamantyl)thiacalix[4]arene in mixtures with chlorinated cobalt dicarbollide was studied. An extraordinary synergistic effect is observed in extraction of europium with p-(1-adamantyl)thiacalix[4]arene tetraacetate derivative. Amides of p-(1-adamantyl)thiacalix-[4]arene tetracarboxylic acid are selective toward europium, although their extraction ability toward the examined ions is lower than that of the classical extractant, p-(1-adamantyl)calix[4]arene tetracarboxylic acid diethylamide.

  研究了使用衍生自对(1-金刚烷基)硫杂杯[4]芳烃的配体与氯化二碳交联钴的混合物中，从稀 HNO3 到二氯乙烷中协同萃取长寿命裂变产物 137Cs+、85Sr2+ 和 152Eu3+。在用对(1-金刚烷基)硫杂[4]芳烃四乙酸酯衍生物萃取铕时观察到了非凡的协同效应。对-(1-金刚烷基)硫代杯-[4]芳烃四甲酸的酰胺对铕具有选择性，但其对所检测离子的萃取能力低于经典萃取剂对-(1-金刚烷基)杯[4]芳烃四甲酸二乙酰胺。