1,1'-di-tert-butyl 3-(1,1,1-trichloro-2-methylpropan-2-yl) 2-methoxy-3,3'-biindoline-1,1',3-tricarboxylate | 1290053-24-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1,1'-di-tert-butyl 3-(1,1,1-trichloro-2-methylpropan-2-yl) 2-methoxy-3,3'-biindoline-1,1',3-tricarboxylate
• CAS: 1290053-24-5
• 化学式: C₃₂H₃₇Cl₃N₂O₇
• 分子量: 668.014
• InChiKey: OLQHULNEUBHPER-XJFCNFDWSA-N

反应信息

• 作为产物：
  描述：

  1,1'-di-tert-butyl 3-(1,1,1-trichloro-2-methylpropan-2-yl) 2-hydroxy-3,3'-biindoline-1,1',3-tricarboxylate 、 原甲酸三甲酯 在 4-甲基苯磺酸吡啶 作用下， 以 甲醇 为溶剂， 反应 12.0h， 生成 1,1'-di-tert-butyl 3-(1,1,1-trichloro-2-methylpropan-2-yl) 2-methoxy-3,3'-biindoline-1,1',3-tricarboxylate 、 1,1'-di-tert-butyl 3-(1,1,1-trichloro-2-methylpropan-2-yl) 2-methoxy-3,3'-biindoline-1,1',3-tricarboxylate
  参考文献：
  名称：

  Enantioselective Total Synthesis of (+)-Gliocladine C: Convergent Construction of Cyclotryptamine-Fused Polyoxopiperazines and a General Approach for Preparing Epidithiodioxopiperazines from Trioxopiperazine Precursors

  摘要：

  A concise second-generation total synthesis of the fungal-derived alkaloid (+)-gliocladin C (11) in 10 steps and 1196 overall yield from isatin is reported. In addition, the epipolythiodioxopiperazine (ETP) natural product (+)-gliocladine C (6) has been prepared in six steps and 2996 yield from the di-(tert-butoxycarbonyl) precursor of 11. The total synthesis of 6 constitutes the first total synthesis of an ETP natural product containing a hydroxyl substituent adjacent to a quaternary carbon stereocenter in the pyrrolidine ring.

  DOI：

  10.1021/ja201789v