2-(((tert-Butyldimethylsilyl)oxy)methyl)-6-(((methoxymethyl)oxy)methyl)pyridine | 150058-65-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(((tert-Butyldimethylsilyl)oxy)methyl)-6-(((methoxymethyl)oxy)methyl)pyridine
• 英文别名: tert-butyl-[[6-(methoxymethoxymethyl)pyridin-2-yl]methoxy]-dimethylsilane
• CAS: 150058-65-4
• 化学式: C₁₅H₂₇NO₃Si
• 分子量: 297.47
• InChiKey: UEGVGVMOGBCXRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.72
• 重原子数：
  20.0
• 可旋转键数：
  7.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  40.58
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2-(((tert-Butyldimethylsilyl)oxy)methyl)-6-(((methoxymethyl)oxy)methyl)pyridine 在 四溴化碳 、 四丁基氟化铵 、 N,N-二异丙基乙胺 、 三苯基膦 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 反应 0.67h， 生成 N,N'-Bis((6-(((methoxymethyl)oxy)methyl)-2-pyridyl)methyl)diaza-18-crown-6
  参考文献：
  名称：

  Side arm effects on cation binding, extraction, and transport functions of oligopyridine-functionalized aza-crown ethers

  摘要：

  A new series of lariat ethers and double-armed crown ethers was prepared in which oligopyridine-functionalized side arms were attached as secondary donor sites. A novel preparative method of oligopyridine derivatives was successfully applied to the synthesis of these crown ethers. Introduction of an oligopyridine-functionalized side arm into the crown ether system, if of the proper chain length and geometrical arrangement, significantly offered three-dimensional complexation with various metal cations suitable for extraction and transport. Liquid-liquid extraction, C-13-NMR binding, and liquid membrane transport experiments revealed that the present type of double-armed crown ethers exhibited cation-binding abilities superior to corresponding lariat ethers.

  DOI：

  10.1021/jo00068a038
• 作为产物：
  描述：

  2-吡啶甲醛,6-[[[(1,1-二甲基乙基)二甲基甲硅烷基]氧代]甲基]- 在 sodium tetrahydroborate 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 2-(((tert-Butyldimethylsilyl)oxy)methyl)-6-(((methoxymethyl)oxy)methyl)pyridine
  参考文献：
  名称：

  Side arm effects on cation binding, extraction, and transport functions of oligopyridine-functionalized aza-crown ethers

  摘要：

  A new series of lariat ethers and double-armed crown ethers was prepared in which oligopyridine-functionalized side arms were attached as secondary donor sites. A novel preparative method of oligopyridine derivatives was successfully applied to the synthesis of these crown ethers. Introduction of an oligopyridine-functionalized side arm into the crown ether system, if of the proper chain length and geometrical arrangement, significantly offered three-dimensional complexation with various metal cations suitable for extraction and transport. Liquid-liquid extraction, C-13-NMR binding, and liquid membrane transport experiments revealed that the present type of double-armed crown ethers exhibited cation-binding abilities superior to corresponding lariat ethers.

  DOI：

  10.1021/jo00068a038