5-fluoro-4-imino-3-methyl-3,4-dihydropyrimidin-2(1H)-one | 1422951-91-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-fluoro-4-imino-3-methyl-3,4-dihydropyrimidin-2(1H)-one
• CAS: 1422951-91-4
• 化学式: C₅H₆FN₃O
• 分子量: 143.121
• InChiKey: LVEZXNMYKXIQQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.67
• 重原子数：
  10.0
• 可旋转键数：
  0.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  61.64
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  3,5-二氯苯甲酰氯 、 5-fluoro-4-imino-3-methyl-3,4-dihydropyrimidin-2(1H)-one 在 N,O-Bis(trimethylsilyl)acetamide 作用下， 以 乙腈 为溶剂， 反应 0.5h， 以35%的产率得到1-(3,5-dichlorobenzoyl)-5-fluoro-4-imino-3-methyl-3,4-dihydropyrimidin-2(1H)-one
  参考文献：
  名称：

  [EN] 1-(SUBSTITUTED-BENZOYL)-5-FLUORO-4-IMINO-3-METHYL-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE DERIVATIVES
  [FR] DÉRIVÉS DE 1-(BENZOYL-SUBSTITUÉ)-5-FLUORO-4-IMINO-3-MÉTHYL-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE

  摘要：

  本公开涉及1-(取代苯甲酰)-5-氟-4-亚胺-3-甲基-3,4-二氢嘧啶-2(1H)-酮及其衍生物的领域，以及这些化合物作为杀菌剂的用途。杀菌剂是天然或合成的化合物，能够保护和/或治疗植物免受农业相关真菌的损害。一般来说，没有单一的杀菌剂适用于所有情况。因此，正在进行研究以生产可能具有更好性能、更易于使用和成本更低的杀菌剂。本公开涉及1-(取代苯甲酰)-5-氟-4-亚胺-3-甲基-3,4-二氢嘧啶-2(1H)-酮化合物及其作为杀菌剂的用途。本公开的化合物可能对包括子囊菌、担子菌、假菌和卵菌在内的真菌和真菌样生物提供保护。

  公开号：

  WO2014105821A1
• 作为产物：
  描述：

  5-fluoro-4-imino-1-((4-methoxyphenyl)sulfonyl)-3-methyl-3,4-dihydropyrimidin-2(1H)-one 在 二甲基硫 、 三氟乙酸 作用下， 以 甲醇 为溶剂， 反应 25.5h， 以96%的产率得到5-fluoro-4-imino-3-methyl-3,4-dihydropyrimidin-2(1H)-one
  参考文献：
  名称：

  [EN] 5-FLUORO-4-IMINO-3-(SUBSTITUTED)-3,4-DIHYDROPYRIMIDIN-2-(1H)-ONE DERIVATIVES
  [FR] DÉRIVÉS DE 5-FLUORO-4-IMINO-3-(SUBSTITUÉ)-3,4-DIHYDROPYRIMIDIN-2-(1H)-ONE

  摘要：

  本公开涉及5-氟-4-亚氨基-3-(取代基)-3,4-二氢嘧啶-2(1H)酮及其衍生物领域，以及这些化合物作为杀真菌剂的用途。

  公开号：

  WO2013025795A1

文献信息

• [EN] N-(SUBSTITUTED)-5-FLUORO-4-IMINO-3-METHYL-2-OXO-3,4-DIHYDROPYRIMIDINE-1 (2H)-CARBOXYLATE DERIVATIVES<br/>[FR] DÉRIVÉS CARBOXYLATES DE N-(SUBSTITUÉ)-5-FLUORO-4-IMINO-3-MÉTHYLE-2-OXO-3,4-DIHYDROPYRIMIDINE-1 (2H)-
  申请人：DOW AGROSCIENCES LLC

  公开号：WO2014105844A1

  公开（公告）日：2014-07-03

  This present disclosure is related to the field of N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1(2H)- carboxylates and their derivatives and to the use of these compounds as fungicides. Also provided are methods of controlling a fungal disease such as Septoria tritici, comprising administering an effective amount of the fungicide compound to at lease one surface associated with the plant, seed or soil.

  本公开涉及N-(取代)-5-氟-4-亚氨基-3-甲基-2-羰基-3,4-二氢嘧啶-1(2H)-羧酸酯及其衍生物领域，以及将这些化合物用作杀菌剂的用途。还提供了控制真菌病如小麦赤霉病的方法，包括向与植物、种子或土壤相关的至少一个表面施用杀菌剂化合物的有效量。
• [EN] N-(SUBSTITUTED)-5-FLUORO-4-IMINO-3-METHYL-2-OXO-3,4-DIHYDROPYRIMIDINE-1 (2H)-CARBOXAMIDES DERIVATIVES<br/>[FR] DÉRIVÉS DE N-(SUBSTITUÉ)-5-FLUORO-4-IMINO-3-MÉTHYL-2-OXO-3,4-DIHYDROPYRIMIDINE-1 (2H)-CARBOXAMIDES
  申请人：DOW AGROSCIENCES LLC

  公开号：WO2014105841A1

  公开（公告）日：2014-07-03

  This present disclosure is related to the field of to N-(substituted)-5-fluoro-4-imino-3-methy1-2-oxo-3,4-dihydropyrimidine-1(2H)-carboxamide compounds and their derivatives and to the use of these compounds as fungicides. This application claims the benefit of U.S. Provisional Patent Application Serial No. 611746,837 filed December 28, 2012, which is expressly incorporated by reference herein. Background and Summary of the Invention Fungicides are compounds, of natural or synthetic origin, which act to protect and/or cure plants against damage caused by agriculturally relevant fungi. Generally, no single fungicide is useful in all situations. Consequently, research is ongoing to produce fungicides that may have better performance, are easier to use, and cost less.

  本公开涉及N-（取代）-5-氟-4-亚胺-3-甲基-2-氧代-3,4-二氢嘧啶-1（2H）-羧酰胺化合物及其衍生物领域，以及这些化合物作为杀真菌剂的用途。本申请声明受益于2012年12月28日提交的美国临时专利申请序列号611746,837，该申请明确地被引用于此。背景和发明的摘要真菌杀菌剂是天然或合成的化合物，它们的作用是保护和/或治疗农业相关真菌对植物造成的损害。一般来说，没有单一的杀菌剂适用于所有情况。因此，研究正在进行中，以生产可能具有更好性能、更易于使用和成本更低的杀菌剂。
• 5-fluoro-4-imino-3,4-dihydropyrimidin-2-(1H)-ones derivatives
  申请人：Boebel Timothy A.

  公开号：US08658660B2

  公开（公告）日：2014-02-25

  This present disclosure is related to the field of 5-fluoro-4-imino-3-(substituted)-3,4-dihydropyrimidin-2(1H)ones and their derivatives and to the use of these compounds as fungicides.

  本公开涉及5-氟-4-亚氨基-3-(取代基)-3,4-二氢嘧啶-2(1H)酮及其衍生物领域，以及这些化合物作为杀真菌剂的用途。
• 5-FLUORO-4-IMINO-3,4-DIHYDROPYRIMIDIN-2-(1H)-ONES DERIVATIVES
  申请人：Boebel Timothy A.

  公开号：US20130045984A1

  公开（公告）日：2013-02-21

  This present disclosure is related to the field of 5-fluoro-4-imino-3-(substituted)-3,4-dihydropyrimidin-2(1H)ones and their derivatives and to the use of these compounds as fungicides.

  本公开涉及5-氟-4-亚氨基-3-(取代基)-3,4-二氢嘧啶-2(1H)酮及其衍生物领域，以及这些化合物作为杀真菌剂的用途。
• 1-(substituted-benzoyl)-5-fluoro-4-imino-3-methyl-3,4-dihydropyrimidin-2(1H)-one derivatives
  申请人：DOW AGROSCIENCES LLC

  公开号：US09271497B2

  公开（公告）日：2016-03-01

  This present disclosure is related to the field of 1-(substituted-benzoyl)-5-fluoro-4-imino-3-methyl-3,4-dihydropyrimidin-2(1H)-ones and their derivatives and to the use of these compounds as fungicides. Fungicides are compounds, of natural or synthetic origin, which act to protect and/or cure plants against damage caused by agriculturally relevant fungi. Generally, no single fungicide is useful in all situations. Consequently, research is ongoing to produce fungicides that may have better performance, are easier to use, and cost less. The present disclosure relates to 1-(substituted-benzoyl)-5-fluoro-4-imino-3-methyl-3,4-dihydropyrimidin-2(1H)-one compounds and their use as fungicides. The compounds of the present disclosure may offer protection against fungi and fungi like organisms including ascomycetes, basidiomycetes, deuteromycetes, and oomycetes.

  本公开涉及1-(取代苯甲酰)-5-氟-4-亚胺-3-甲基-3,4-二氢嘧啶-2(1H)-酮及其衍生物的领域，以及这些化合物作为杀真菌剂的用途。杀真菌剂是天然或合成的化合物，可保护和/或治愈农业相关真菌对植物造成的损害。通常，没有单一的杀真菌剂适用于所有情况。因此，正在进行研究以生产可能具有更好性能、更易于使用且成本更低的杀真菌剂。本公开涉及1-(取代苯甲酰)-5-氟-4-亚胺-3-甲基-3,4-二氢嘧啶-2(1H)-酮化合物及其作为杀真菌剂的用途。本公开的化合物可能对包括子囊菌、担子菌、无性菌和卵菌在内的真菌和真菌类生物提供保护。